Hypericum para Inducción enzimática (Interacción farmacológica)
Hypericum sinaicum — 11 estudios científicos revisados
Strong¿Sirve Hypericum para inducción enzimática (interacción farmacológica)?
La presencia de hiperforina y otros metabolitos puede inducir las enzimas del citocromo P450, lo que acelera la eliminación de medicamentos sintéticos del cuerpo.
Compuestos activos involucrados: {'name': 'Hipericina', 'class': 'Naftodiantrona'}, {'name': 'Pseudohipericina', 'class': 'Naftodiantrona'}, {'name': 'Sinaicinona', 'class': 'Adamantano'}, {'name': 'Quercetina', 'class': 'Flavonoide'}
Evidencia Científica
Los siguientes estudios han investigado la relación entre Hypericum y inducción enzimática (interacción farmacológica):
Herbal medicines in the treatment of psychiatric disorders: 10-year updated review.
This paper provides a 10-year update of the 2007 systematic review of herbal medicines studied in a broad range of psychiatric disorders, including depression, anxiety, obsessive-compulsive, seasonal affective, bipolar, psychotic, phobic, somatoform, and attention-deficit hyperactivity disorders. Ovid Medline, PubMed, and the Cochrane Library were searched for herbal medicines with both pharmacological and clinical evidence of psychotropic activity. This updated review now covers clinical trial evidence for 24 herbal medicines in 11 psychiatric disorders. High-quality evidence was found to exi
PubMed: 29575228Ethnobotanical and ethnomedicinal research into medicinal plants in the Mt Stara Planina region (south-eastern Serbia, Western Balkans).
BACKGROUND: Ethnobotanical research in Southeast Europe-one of the most important European hotspots for biocultural diversity-is significant for the acquisition of Traditional Ecological Knowledge related to plants as well as for encouraging the development of local environments. The current ethnobotanical research was conducted in the region of Mt Stara Planina (south-eastern Serbia), which is characterised by rich phytodiversity with a large number of endemic and relict plant species. The aim of the study was to document the diversity of uses of medicinal plants and of traditional knowledge
PubMed: 38200599Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research.
Depression is one of the most common diseases in the world, and it is also the most common mental disorder. Depressive disorders are a real threat not only to individuals, but also to the general population. This disease is a leading cause of disability and inability to work. Due to the numerous side effects of conventional drugs, attention is increasingly being paid to other solutions, including herbal medicines. Many plant species are known for their traditional uses in the treatment of anxiety, insomnia, and depression.
PubMed: 39598400Pharmacokinetic and pharmacodynamic herb-drug interactions-part I. Herbal medicines of the central nervous system.
Unlike conventional drug substances, herbal medicines are composed of a complex of biologically active compounds. Therefore, the potential occurrence of herb-drug interactions is even more probable than for drug-drug interactions. Interactions can occur on both the pharmacokinetic and pharmacodynamic level. Herbal medicines may affect the resulting efficacy of the concomitantly used (synthetic) drugs, mainly on the pharmacokinetic level, by changing their absorption, distribution, metabolism, and excretion. Studies on the pharmacodynamic interactions of herbal medicines and conventional drugs
PubMed: 38025741A review of effective herbal medicines in controlling menopausal symptoms.
BACKGROUND: Acute menopausal syndrome especially hot flashes, is one of the most common gynecological problems during menopause. Due to the side effects of hormone therapy, herbal and complementary medicines are always of immense interest to people in the treatment and management of the symptoms and complications of menopause. OBJECTIVE: The aim of this study was to investigate the mechanisms and effects of medicinal plants employed in the treatment of menopausal symptoms. METHODS: This review article was carried out by examining clinical trial studies between the period of 1994 and 2016. The
PubMed: 29403626Seguridad y Precauciones
La seguridad del uso de Hypericum sinaicum es un área de estudio compleja debido a su perfil fitoquímico. Se ha identificado la presencia de compuestos como la hipericina, protohipericina y pseudohipericina [PMID 19791496], así como la hiperforina [PMID 19791496], los cuales son conocidos por inducir enzimas metabólicas. En cuanto al embarazo y la lactancia, no existen estudios clínicos exhaustivos que determinen la seguridad de Hypericum sinaicum en estas etapas. Debido a que compuestos similares (como la hipericina) pueden atravesar la barrera placentaria y la lactancia, y dado que el impacto en el desarrollo fetal es desconocido, su uso está contraindicado en mujeres gestantes y lactantes para evitar riesgos de toxicidad neonatal o complicaciones en el desarrollo. Para niños menores de 12 años, el uso no se recomienda. El sistema enzimático hepático y el sistema nervioso de los infantes están en desarrollo, y la falta de datos sobre la dosis segura en pediatría hace que el riesgo de efectos adversos sea inaceptablemente alto.
Otras plantas estudiadas para Inducción enzimática (Interacción farmacológica)
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