Té de Bogotá para Estrés oxidativo
Ilex kunthiana — 9 estudios científicos revisados
Preliminary¿Sirve Té de Bogotá para estrés oxidativo?
Especies congéneres del género Ilex demuestran actividad antioxidante significativa mediada por ácido clorogénico y flavonoides, compuestos probablemente presentes en I. kunthiana.
Compuestos activos involucrados: cafeína, ácido clorogénico, saponinas triterpénicas, flavonoides, ácido ursólico, quercetina, Rutina, Saponinas, Teobromina, Teofilina, Xantina, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Té de Bogotá y estrés oxidativo:
Ilex paraguariensis Attenuates Changes in Mortality, Behavioral and Biochemical Parameters Associated to Methyl Malonate or Malonate Exposure in Drosophila melanogaster.
Methylmalonic acidemia is a genetic disease characterized by accumulation of organic acids, such as methylmalonic (MMA) and malonic (MA) acids. Considering that the accumulation of MMA and MA causes several damages due to oxidative stress, antioxidants are thought to play a pivotal role in preventing deleterious effects associated with exposure to such compounds. Ilex paraguariensis (IP) was used here to test the hypothesis that supplementation with the aqueous extract of this plant could exert protective effect against MMA or MA induced mortality, behavioral and/or biochemical changes in Dros
PubMed: 31422521Ilex asprella polysaccharides alleviate liver injury via antioxidative, anti-inflammatory, and gut microbiota modulating effect.
Ilex asprella, a valued plant traditionally used as food and medicine, is recognized for its effect on liver protection. Polysaccharides, as the key active components in Ilex asprella (IAP), its biological activities are still unexplored. Therefore, this study investigated the preventive effects of IAP on liver injury in vivo. H&E and TUNEL staining revealed IAP could ameliorate the histomorphology changes and liver apoptosis. For antioxidant ability, IAP preconditioning released D-GalN/LPS-induced oxidative stress via Nrf2/HO-1 signaling pathway in liver, as evidenced by increasing superoxide
PubMed: 40081689Yerba Mate Tea (Ilex paraguariensis): a comprehensive review on chemistry, health implications, and technological considerations.
Yerba Mate tea, an infusion made from the leaves of the tree Ilex paraguariensis, is a widely consumed nonalcoholic beverage in South America which is gaining rapid introduction into the world market, either as tea itself or as ingredient in formulated foods or dietary supplements. The indigenous people have used it for centuries as a social and medicinal beverage. Yerba Mate has been shown to be hypocholesterolemic, hepatoprotective, central nervous system stimulant, diuretic, and to benefit the cardiovascular system. It has also been suggested for obesity management. Yerba Mate protects DNA
PubMed: 18034743Clofarabine.
Clofarabine [Clofarex] is a purine nucleoside in development with Bio-envision, the Southern Research Institute and ILEX Oncology as an anticancer agent. Clofarabine's nucleoside structure is such that both the purine and ribose rings are halogenated, which allows it to inhibit DNA synthesis at two critical junctures: DNA polymerase I and RNA reductase. An intravenous infusion and an oral formulation are undergoing clinical development. Clofarabine was originated by the Southern Research Institute. In August 1998 Bioenvision signed a co-development agreement with the Southern Research Institut
PubMed: 15230627Alemtuzumab (Millennium/ILEX).
Alemtuzumab, a lymphocyte-depleting humanized monoclonal antibody, is being developed by Millennium Pharmaceuticals Inc and ILEX Oncology for the potential treatment of chronic lymphocytic leukemia (CLL) [274580]. The utility of the compound for treating bone marrow (BM) stem cell transplantation-associated graft-versus-host disease (GVHD) [372946] and for ex vivo purging of BM to remove malignant T-cells [244056] is also being investigated. Additional potential therapeutic areas for which clinical trials are planned or ongoing include vasculitis, multiple sclerosis [288762] and organ transpla
PubMed: 11527007Contexto Científico
Una revisión comprehensiva sobre Ilex paraguariensis, la especie más estudiada del género, documenta extensamente las propiedades antioxidantes, antiinflamatorias, termogénicas y cardioprotectoras asociadas a los compuestos que comparten las especies de Ilex: ácido clorogénico, saponinas triterpénicas, cafeína y flavonoides (PMID 32588612).
Seguridad y Precauciones
No existen estudios de seguridad ni toxicología publicados para Ilex kunthiana. Las precauciones se basan en el perfil de seguridad conocido del género Ilex y en la probable presencia de cafeína y compuestos relacionados. Si la planta contiene cafeína, como es probable para una especie de Ilex usada como estimulante, se aplican las precauciones generales para bebidas con cafeína: el consumo excesivo puede causar insomnio, nerviosismo, taquicardia, irritabilidad y malestar gastrointestinal. Se recomienda limitar el consumo a 2-3 tazas diarias y evitar la ingesta después de las 4 de la tarde. Personas con trastornos de ansiedad, arritmias cardíacas, hipertensión arterial no controlada o úlcera gástrica deben moderar o evitar el consumo, como con cualquier bebida estimulante. La cafeína puede interactuar con medicamentos como efedrina (riesgo cardiovascular), adenosina (reduce su efecto), litio (aumenta niveles plasmáticos) y ciertos antibióticos fluoroquinolonas (ciprofloxacino inhibe el metabolismo de la cafeína).
Otras plantas estudiadas para Estrés oxidativo
Perfil completo: Ver todos los usos y evidencia de Té de Bogotá →