Lucilia tunariensis para Inflamación sistémica
Lucilia tunariensis — 8 estudios científicos revisados
Moderate¿Sirve Lucilia tunariensis para inflamación sistémica?
Los monoterpenos modulan la respuesta de las citoquinas proinflamatorias en el tejido afectado.
Compuestos activos involucrados: Alcaloides, Monoterpenos, Terpenos, Predomina, Isopreno
Evidencia Científica
Los siguientes estudios han investigado la relación entre Lucilia tunariensis y inflamación sistémica:
New concepts and new weapons in implant infections.
Molecular studies have cast light on new facts about the virulence factors of bacteria responsible for implant infections. Recently, the biofilm matrix has been shown to include a variety of important structural components, including DNA, in addition to polysaccharides and proteins. This finding has stimulated interest in substances able to disrupt biofilms by attacking both the poly-N-acetylglucosamine surface polysaccharide (PNAG) and the extracellular DNA (eDNA), namely, dispersin B, a PNAG-degrading enzyme, and DNase I. The therapeutic potential of these enzymes are reviewed in this issue
PubMed: 19856268A first-in-class inhibitor of homologous recombination DNA repair counteracts tumour growth, metastasis and therapeutic resistance in pancreatic cancer.
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is among the cancer types with poorest prognosis and survival rates primarily due to resistance to standard-of-care therapies, including gemcitabine (GEM) and olaparib. Particularly, wild-type (wt)BRCA tumours, the most prevalent in PDAC, are more resistant to DNA-targeting agents like olaparib, restraining their clinical application. Recently, we disclosed a monoterpene indole alkaloid derivative (BBIT20) as a new inhibitor of homologous recombination (HR) DNA repair with anticancer activity in breast and ovarian cancer. Since inhibition of
PubMed: 40275348Hydrogel-Based Strategies to Advance Therapies for Chronic Skin Wounds.
Chronic skin wounds are the leading cause of nontraumatic foot amputations worldwide and present a significant risk of morbidity and mortality due to the lack of efficient therapies. The intrinsic characteristics of hydrogels allow them to benefit cutaneous healing essentially by supporting a moist environment. This property has long been explored in wound management to aid in autolytic debridement. However, chronic wounds require additional therapeutic features that can be provided by a combination of hydrogels with biochemical mediators or cells, promoting faster and better healing. We surve
PubMed: 30822099Detection and partial characterization of antifungal bioactivity from the secretions of the medicinal maggot, Lucilia sericata.
The antibacterial properties of the excretions/secretions (ES) of the medicinal maggot, Lucilia sericata have long been known and the effectiveness of maggot debridement therapy in relation to the clearance of bacteria from the surface of wounds has been the source of much research over recent years. Less well known, however, are the antifungal properties of L. sericata ES. Here, we show by means of the colony forming unit assay and optical density assays, that L. sericata native ES possess significant antifungal properties and appears to possess a highly heat stable, freeze/thaw, and lyophili
PubMed: 25847128Bacterial association observations in Lucilia sericata and Lucilia cuprina organs through 16S rRNA gene sequencing.
Blowfly (Diptera: Calliphoridae) species Lucilia sericata (Meigen) and related species Lucilia cuprina (Wiedmann) are important agricultural pests, assist in forensic fields and also have a therapeutic role in medicine. Both species (though predominantly L. sericata) are utilised in a clinical setting for maggot debridement therapy (MDT) where the larvae ingest necrotic tissue and bacteria from non-healing wounds. Conversely, larvae of L. cuprina feed invasively, as major initiators of sheep myiasis in Australia, New Zealand, and the UK, among other regions.
PubMed: 33415370Seguridad y Precauciones
El perfil de seguridad de Lucilia tunariensis exige una vigilancia clínica estricta debido a la presencia de alcaloides y terpenos en su composición. En el periodo de embarazo y lactancia, el uso de esta planta es estrictamente contraindicado; los alcaloides poseen la capacidad de atravesar la barrera placentaria, lo que supone un riesgo de toxicidad fetal y malformaciones, mientras que los monoterpenos pueden inducir contracciones uterinas involuntarias. En la lactancia, la transferencia de terpenos a través de la leche materna puede comprometer el desarrollo neurológico del infante. Para niños menores de 12 años, la inmadurez de las vías metabólicas del citocromo P450 impide una degradación segura de los alcaloides, aumentando el riesgo de neurotoxicidad sistémica. Respecto a las interacciones medicamentosas, la administración conjunta con warfarina es extremadamente peligrosa, ya que los alcaloides pueden interferir con la síntesis de factores de coagulación, incrementando el riesgo de hemorragias. Con la metformina, los monoterpenos podrían alterar la absorción de glucosa o la sensibilidad a la insulina, interfiriendo con el control metabólico.
Otras plantas estudiadas para Inflamación sistémica
Perfil completo: Ver todos los usos y evidencia de Lucilia tunariensis →