Luehea para Estrés oxidativo
Luehea grandiflora — 14 estudios científicos revisados
Preclinical¿Sirve Luehea para estrés oxidativo?
Los compuestos fenólicos de Luehea grandiflora mostraron actividad antioxidante en ensayos in vitro.
Compuestos activos involucrados: Flavonoides, Terpenoides, Polifenoles, β-Sitosterol, Friedelinol, Taninos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Luehea y estrés oxidativo:
Aqueous leaf extract from Luehea divaricata Mart. Modulates oxidative stress markers in the spinal cord of rats with neuropathic pain.
ETHNOPHARMACOLOGICAL RELEVANCE: Reactive oxygen species (ROS) play an important role in neuropathic pain (i.e., pain caused by lesion or disease of the somatosensory system). We showed previously that the aqueous extract prepared from Luehea divaricata leaves, a plant explored by native ethnic groups of Brazil to treat different pathologic conditions, exhibits good antioxidant activity and induces analgesia in rats with neuropathic pain (J Ethnopharmacol, 2020; 256:112761. doi: 10.1016/j.jep.2020.112761). The effect was comparable to that of gabapentin, a drug recommended as first-line treatme
PubMed: 33301911Phytochemical analysis and modulation of antibiotic activity by Luehea paniculata Mart. & Zucc. (Malvaceae) in multiresistant clinical isolates of Candida spp.
The high incidence of fungal infections has led to the continuous search for new drugs. Extracts of Luehea paniculata, a tree of multiple medicinal uses, were evaluated for anti-Candida activity, as well as its modulator potential of the Fluconazole antibiotic. Chemical prospecting of ethanol extracts of leaf and bark was carried out, the quantification of total phenols and flavonoids, characterized by the HPLC-DAD technique. The rosmarinic acid and the vitexin flavonoid were observed as major constituents in ELELP and ESWELP, respectively. Antioxidant activity was also evaluated by the method
PubMed: 25821822Ethnopharmacological approaches to kidney disease-prospecting an indigenous species from Brazilian Pantanal.
ETHNOPHARMACOLOGICAL RELEVANCE: Although Luehea divaricata Mart. (Malvaceae) is popularly used by the population of the Brazilian Pantanal for the treatment of different types of kidney diseases, no study has been carried out to prove this ethnobotanical indication. AIM: To investigate the possible cardiorenal effects of an herbal preparation obtained from L. divaricata leaves. MATERIALS AND METHODS: First, to provide quality control standards, a detailed morphological and microchemical characterization of L.
PubMed: 28942138Constituents from stem barks of Luehea ochrophylla Mart and evaluation of their antiparasitic, antimicrobial, and antioxidant activities.
Luehea species are found in almost all Central and South American countries. The present work describes the phytochemical study, isolation, and structural characterisation of friedelin, β-friedelinol, lupeol, pseudotaraxasterol, β-sitosterol, betulinic acid, taraxasterol, (-)-epicatechin, β-sitosterol-3-O-β-d-glucopyranoside, and (+)-epicatechin-(4β→8)-epicatechin from stem barks of Luehea ochrophylla Mart. The structural identification of the isolated compounds was mainly performed by NMR analyses and comparison with the data from literature. These compounds were isolated for the first time i
PubMed: 27966397Trade-offs underlying polyphagy in a facultative ant-tended florivorous butterfly: the role of host plant quality and enemy-free space.
The underlying mechanisms mediating the use of multiple host plants were investigated in Parrhasius polibetes (Lycaenidae), a florivorous and facultative myrmecophilous butterfly. Plant traits such as presence of ant-treehopper associations as a source of enemy-free space, flower bud dimensions, toughness, thickness, trichomes, and the corresponding performance and wear of P. polibetes mandibles were examined for three natural hosts: Schefflera vinosa (Araliaceae), Pyrostegia venusta (Bignoniaceae) and Luehea grandiflora (Malvaceae). Parasitism levels of larvae found on the three hosts were al
PubMed: 20383529Contexto Científico
One study investigated the mutagenic potential of Luehea divaricata using the SMART/wing assay in Drosophila melanogaster (fruit flies), which is an in vivo model used to detect DNA damage. Another study focused on the antimicrobial and antioxidant properties of Luehea ochrophylla stem bark extracts. Furthermore, the extracts showed a high capacity to capture free radicals (antioxidant activity) when compared to ascorbic acid. This means that in a controlled lab setting, the plant components showed promise in fighting microscopic parasites and fungi, as well as protecting cells from oxidative stress. Therefore, while the laboratory evidence is promising for anti-inflammatory, antioxidant, and antiparasitic activities, it should not be viewed as a replacement for medical treatment or as definitive proof of efficacy in humans.
Seguridad y Precauciones
En cuanto al uso durante el embarazo y la lactancia, no existe evidencia científica suficiente en humanos que garantice la seguridad del consumo de Luehea grandiflora o sus parientes cercanos (Luehea divaricata/ochrophylla) en estas etapas. Debido a que los compuestos bioactivos, como los flavonoides (por ejemplo, isovitexina) y triterpenos, pueden atravesar la barrera placentaria o ser excretados en la leche materna, se recomienda evitar su uso. La falta de estudios toxicológicos específicos en modelos gestacionales implica un riesgo potencial de alteraciones en el desarrollo fetal o efectos sistémicos en el lactante. Para niños menores de 12 años, el uso debe ser estrictamente evitado. Los sistemas fisiológicos en desarrollo, particularmente el metabolismo hepático y la función renal, son más susceptibles a los efectos de los metabolitos secundarios de las plantas. No se han establecido dosis máximas seguras para la población pediátrica, y el riesgo de toxicidad aguda o crónica es impredecible.
Otras plantas estudiadas para Estrés oxidativo
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