Luehea para Inflamación
Luehea grandiflora — 3 estudios científicos revisados
Preclinical¿Sirve Luehea para inflamación?
Los polifenoles y terpenoides de Luehea grandiflora han mostrado actividad antiinflamatoria en modelos de edema en roedores.
Compuestos activos involucrados: Flavonoides, Terpenoides, Polifenoles, β-Sitosterol, Friedelinol, Taninos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Luehea y inflamación:
Anti-inflammatory and cytotoxic activities of the extracts, fractions, and chemical constituents isolated from Luehea ochrophylla Mart.
BACKGROUND: Stem bark of Luehea ochrophylla (L. ochrophylla) is used by the traditional Brazilian medicine for treatment of rheumatic diseases and tumors. This study aimed to investigate inhibition of acute and chronic inflammations and cytotoxic activity of extracts, fractions, and isolated compounds from L. ochrophylla. METHODS: Hexane (HE) and ethanol (EE) extracts obtained from stem bark of L.
PubMed: 31660940Molecular characterization by amplified ribosomal DNA restriction analysis and antimicrobial potential of endophytic fungi isolated from Luehea divaricata (Malvaceae) against plant pathogenic fungi and pathogenic bacteria.
Luehea divaricata is an important plant in popular medicine; it is used for its depurative, anti-inflammatory, and other therapeutic activities. We evaluated the antimicrobial activity of endophytic fungi isolated from leaves of L. divaricata against phytopathogens and pathogenic bacteria, and characterized the isolates based on amplified ribosomal DNA restriction analysis (ARDRA). The in vitro antagonistic activity of these endophytes against the phytopathogen Alternaria alternata was assayed by dual culture technique. Based on this evaluation of antimicrobial activity, we extracted secondary
PubMed: 24301768Aqueous extract from Luehea divaricata Mart. Leaves reduces nociception in rats with neuropathic pain.
ETHNOPHARMACOLOGICAL RELEVANCE: Luehea divaricata, popularly known in Brazil as "açoita-cavalo", has been widely explored by different ethnic groups native to Brazil to treat different pathologic conditions, including inflammatory pain. However, no report could be found on the effect that extract of L. divaricata has on neuropathic pain. This is an important topic because convergent and divergent mechanisms underlie inflammatory vs. neuropathic pain indicate that there may not always be a clear mechanistic delineation between these two conditions.
PubMed: 32171894Contexto Científico
Research also explored the anti-inflammatory and cytotoxic effects of Luehea ochrophylla. The researchers tested the ability of extracts to reduce inflammation and kill cancer cells [PMID 31660940]. Results showed that the ethyl acetate fraction significantly reduced lymphocyte proliferation (an indicator of immune response/inflammation) and that certain compounds, like β-sitosterol-3-O-β-D-glucopyranoside, exhibited high cytotoxic activity against various cell lines. Therefore, while the laboratory evidence is promising for anti-inflammatory, antioxidant, and antiparasitic activities, it should not be viewed as a replacement for medical treatment or as definitive proof of efficacy in humans.
Seguridad y Precauciones
En cuanto al uso durante el embarazo y la lactancia, no existe evidencia científica suficiente en humanos que garantice la seguridad del consumo de Luehea grandiflora o sus parientes cercanos (Luehea divaricata/ochrophylla) en estas etapas. Debido a que los compuestos bioactivos, como los flavonoides (por ejemplo, isovitexina) y triterpenos, pueden atravesar la barrera placentaria o ser excretados en la leche materna, se recomienda evitar su uso. La falta de estudios toxicológicos específicos en modelos gestacionales implica un riesgo potencial de alteraciones en el desarrollo fetal o efectos sistémicos en el lactante. Para niños menores de 12 años, el uso debe ser estrictamente evitado. Los sistemas fisiológicos en desarrollo, particularmente el metabolismo hepático y la función renal, son más susceptibles a los efectos de los metabolitos secundarios de las plantas. No se han establecido dosis máximas seguras para la población pediátrica, y el riesgo de toxicidad aguda o crónica es impredecible.
Otras plantas estudiadas para Inflamación
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