Manayupa para Bronquitis crónica y asma
Desmodium adscendens — 8 estudios científicos revisados
Moderate¿Sirve Manayupa para bronquitis crónica y asma?
La planta contiene fracciones que inhiben las contracciones de los espirales traqueales inducidas por histamina y carbachol, lo que ayuda a relajar las vías respiratorias [PMID 2120518].
Compuestos activos involucrados: flavonoides, saponinas, triterpenoides, alcaloides, Quercetrina, Terpenoides, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Manayupa y bronquitis crónica y asma:
Feasibility single-arm study of a medical device containing
BACKGROUND: Neoplasms of the head and neck represent approximately 5% of cancers and they require complex multidisciplinary clinical management. AIM: In this single-arm study, we investigated the efficacy of a combination therapy based on Desmovit METHODS: Twelve patients with histological or cytological diagnosis of stage IV head and neck cancer were enrolled in this study that was approved by the ethics committee of the Unità Operativa Complessa (UOC) di Oncologia Medica Azienda Ospedaliera Ospedali Riuniti Marche Nord and followed the Declaration of Helsinki guidelines. The patients were mo
PubMed: 30519091An ethnomedicinal, phytochemical and pharmacological profile of Desmodium gangeticum (L.) DC. and Desmodium adscendens (Sw.) DC.
ETHNOPHARMACOLOGICAL RELEVANCE: Desmodium gangeticum (L.) DC. and Desmodium adscendens (Sw.) DC. are two important and well explored species of genus Desmodium (Fabaceae (alt. Leguminosae) subfamily: Faboideae). Desmodium gangeticum is used as a tonic, febrifuge, digestive, anticatarrhal, antiemitic, in inflammatory conditions of chest and in various other inflammatory conditions in the Ayurvedic System of Medicine while Desmodium adscendens is widely used for the treatment of asthma in Ghana, Africa.
PubMed: 21530632Some secondary plant metabolites in Desmodium adscendens and their effects on arachidonic acid metabolism.
The effects of three chemically different groups of compounds, (triterpenoid saponins, beta-phenylethylamines and tetrahydroisoquinolines), known to be present in Desmodium adscendens, on plasma membrane ion channel, cytochrome P450 NADPH-dependent oxygenation of arachidonic acid, and production of prostaglandins by the cyclooxygenase enzyme system, are described. The very high-conductance calcium-activated potassium ion channel, which is responsible for the maintenance of tone in smooth muscles, was activated by the saponins. The cytochrome P450 NADPH-dependent monooxygenase reaction, which p
PubMed: 1438471Qualitative characterization of Desmodium adscendens constituents by high-performance liquid chromatography-diode array ultraviolet-electrospray ionization multistage mass spectrometry.
The many effects of the African medicinal herb Desmodium adscendens were studied in the 1980s and 1990s. In spite of this, a comprehensive analytical protocol for the quality control of its constituents (soyasaponins, alkaloids and flavonoids) has not yet been formulated and reported. This study deals with the optimization of extraction conditions from the plant and qualitative identification of the constituents by HPLC-diode array UV and multistage mass spectrometry. Plant constituents were extracted from leaves by liquid-liquid and solid matrix dispersion extraction. Separation was achieved
PubMed: 23841221Pharmacognostical study of Desmodium caudatum.
Desmodium caudatum (Thunb.) DC, is an ever-green plant widely used in the central and southern China with great economic value for their medical values on fever, dysentery, gastroenteritis, rectal prolapse, snake bites, mastitis, and boils carbuncle. Despite its extensive uses as a traditional Chinese medicine, no systematic research on the identification of Desmodium caudatum has been reported. In this study, traditional pharmacognostical identification including the botanical origin and morphological characters, medicinal material characters, microscopic characters, physicochem
PubMed: 31241702Seguridad y Precauciones
El uso de la Manayupa (Desmodium adscendens) requiere una precaución extrema debido a la falta de estudios clínicos extensos en humanos que garanticen su seguridad absoluta. En relación con el embarazo y la lactancia, no existe evidencia científica que determine si los compuestos como los flavonoides o las saponinas presentes en la planta atraviesan la barrera placentaria o se excretan en la leche materna; por lo tanto, su uso está contraindicado en mujeres gestantes y lactantes para evitar riesgos potenciales al desarrollo fetal o neonatal. En niños menores de 12 años, el uso debe evitarse por completo, ya que sus sistemas metabólicos (hepático y renal) están en desarrollo y la toxicidad celular observada en concentraciones altas en estudios in vitro sugiere que podrían ser altamente vulnerables a efectos adversos. Respecto a las interacciones farmacológicas, la planta presenta riesgos significativos: la presencia de compuestos con actividad sobre el sistema nervioso central (efectos sedantes y de tipo serotonérgico observados en modelos animales [PMID 28710881]) podría potenciar peligrosamente fármacos psicotrópicos o ansiolíticos. Asimismo, debido a su potencial actividad sobre el metabolismo de ácidos grasos y la posible influencia en procesos enzimáticos, podría interferir con fármacos como la warfarina (alterando la coagulación) o la metformina. El uso de antihipertensivos debe ser vigilado debido a la capacidad de la planta para afectar la contractilidad del músculo liso [PMID 2120518].
Perfil completo: Ver todos los usos y evidencia de Manayupa →