Manayupa para Estrés oxidativo renal
Desmodium adscendens — 5 estudios científicos revisados
Preliminary¿Sirve Manayupa para estrés oxidativo renal?
En concentraciones bajas, el extracto ha mostrado capacidad de protección contra el estrés oxidativo en células renales (LLC-PK1) [PMID 26401376].
Compuestos activos involucrados: flavonoides, saponinas, triterpenoides, alcaloides, Quercetrina, Terpenoides, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Manayupa y estrés oxidativo renal:
Safety of Desmodium adscendens extract on hepatocytes and renal cells. Protective effect against oxidative stress.
AIM: The increased consumption of traditional medicinal plants has been driven by the notion that herbal products are safe and efficient. The purpose of this study was to evaluate the safety and the protective effect of a hydro alcoholic extract of Desmodium adscendens (DA) on liver (HEPG2) and kidney (LLC-PK1) cells. MATERIALS AND METHODS: A hydro alcoholic extract of DA was used. HEPG2 or LLC-PK1 cells were treated with different does of DA, and viability test (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium [MTS]), cytotoxicity assay lactate dehydrog
PubMed: 26401376Therapeutic potential of Desmodium styracifolium polysaccharide in attenuating nano-calcium oxalate induced renal injury and fibrosis.
Calcium salt deposition in the kidney induces epithelial-to-mesenchymal transition (EMT) in renal tubular epithelial cells, which is the pathological basis for the progression to renal fibrosis in patients with renal stones; however, effective drugs to prevent and treat this disease have not been adequately investigated. In this study, we conducted a comprehensive analysis of fibrosis-related core genes by utilizing bioinformatics on RNA-seq data, along with web database information. Additionally, we designed both in vivo and in vitro experiments to elucidate the mechanisms and signaling pathw
PubMed: 40897849Desmodium caudatum (Thunb.) DC. extract attenuates hyperuricemia-induced renal fibrosis via modulating TGF-β1 pathway and uric acid transporters: Evidence from in vitro and in vivo studies.
ETHNOPHARMACOLOGICAL RELEVANCE: Desmodium caudatum (Thunb.) DC., a traditional Chinese medicinal herb, has been used to treat conditions such as rheumatic back pain, diarrhea, jaundice-related hepatitis, and abscesses; it also serves as an anthelmintic. The extract of Desmodium caudatum (Thunb.) DC. (DCE) is also known for its antioxidant and anti-inflammatory properties. However, its impact on kidney fibrosis remains unclear. AIM OF THE STUDY: This study investigated whether DCE can alleviate hyperuricemia-induced kidney fibrosis by modulating the transforming growth factor-β1 (TGF-β1) pathwa
PubMed: 40064319A Review of Traditional Medicinal Plants from Kachin State, Northern Myanmar.
Medicinal plants are a vital source of medication in developing countries. In Kachin State, Northern Myanmar, the people have a long history of the use of traditional plants for medicinal purposes. This article deals with the 25 most used medicinal plants in Kachin State. They are: Drynariafortunei, Tetrastigma serrulatum, Bauhinia championii, Goniothalamus cheliensis, Juglans regia, Houttuynia cordata, Osmanthus fragrans, Pothos chinensis, Tabemaemontana coronaria, Eryngiumfoetidum, Chloranthus spicatus, Peperomia pellucida, Zanthoxylum armatum, Polygonumfagopyrum, Cymbidiumfloribundum, Amomu
PubMed: 27169181Total favonoids of Desmodium Styracifolium relieve renal ischemia-reperfusion injury by suppressing ferroptosis through P53/SLC7A11/GPX4 signaling pathway.
Renal ischemia/reperfusion injury (RIRI), a common complication of renal transplantation, partial nephrectomy, and transient hypoperfusion, is a major etiological factor of acute kidney injury (AKI) with limited treatment options. Total flavonoids from Desmodium styracifolium (TFDS), a traditional Chinese medicinal herb used in urinary disorders, have shown promising renoprotective properties. This study aimed to investigate the efficacy of TFDS against RIRI and elucidate its underlying mechanisms, with a particular focus on oxidative stress and ferroptosis. A RIRI model was established in C57
PubMed: 41065914Seguridad y Precauciones
El uso de la Manayupa (Desmodium adscendens) requiere una precaución extrema debido a la falta de estudios clínicos extensos en humanos que garanticen su seguridad absoluta. En relación con el embarazo y la lactancia, no existe evidencia científica que determine si los compuestos como los flavonoides o las saponinas presentes en la planta atraviesan la barrera placentaria o se excretan en la leche materna; por lo tanto, su uso está contraindicado en mujeres gestantes y lactantes para evitar riesgos potenciales al desarrollo fetal o neonatal. En niños menores de 12 años, el uso debe evitarse por completo, ya que sus sistemas metabólicos (hepático y renal) están en desarrollo y la toxicidad celular observada en concentraciones altas en estudios in vitro sugiere que podrían ser altamente vulnerables a efectos adversos. Respecto a las interacciones farmacológicas, la planta presenta riesgos significativos: la presencia de compuestos con actividad sobre el sistema nervioso central (efectos sedantes y de tipo serotonérgico observados en modelos animales [PMID 28710881]) podría potenciar peligrosamente fármacos psicotrópicos o ansiolíticos. Asimismo, debido a su potencial actividad sobre el metabolismo de ácidos grasos y la posible influencia en procesos enzimáticos, podría interferir con fármacos como la warfarina (alterando la coagulación) o la metformina. El uso de antihipertensivos debe ser vigilado debido a la capacidad de la planta para afectar la contractilidad del músculo liso [PMID 2120518].
Otras plantas estudiadas para Estrés oxidativo renal
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