Limonaria para Inflamación
Murraya paniculata — 10 estudios científicos revisados
Moderate¿Sirve Limonaria para inflamación?
En las células, el extracto inhibió la proliferación celular y la migración, además de reducir la expresión de marcadores inflamatorios como iNOS y COX-2.
Compuestos activos involucrados: Alcaloides, Cubenol, Flavonoides, Luteolina, Metilsalicilato, Saponinas, Terpenos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Limonaria y inflamación:
A comprehensive review of the botany, phytochemistry, pharmacology, and toxicology of Murrayae Folium et Cacumen.
Ethnopharmacological relevance: Murrayae Folium et Cacumen (MFC) is a plant considered to be a traditional Chinese medicine with culinary value as well. The dry leaves and twigs of Murraya paniculata and M. exotica are used to treat stomach aches, rheumatism, toothaches, swelling, and insect and snake bites. They are also used to prepare spicy chicken dishes. Aim of the review: This review comprehensively summarizes the available information on the botanical characterization, phytochemistry, pharmacological activities, pharmacodynamics, pharmacokinetics, and toxicity of MFC.
PubMed: 38606170Ameliorating Effects of Murraya paniculata (L.) Jack Extract on Arthritis via Suppressing Multi-Target-Mediated Synovial Hyperplasia, Inflammation, and Oxidative Stress.
INTRODUCTION: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent inflammation, synovial hyperplasia, and osteochondral damage. Murraya paniculata (L.) Jack (MP), a botanical source of Murrayae Folium et Cacumen (MFC), has not previously been investigated for its potential arthritis-protective effects and underlying mechanisms, prompting our study of MP in this context. OBJECTIVES: This study is aimed at evaluating the ameliorating effects of MP and elucidating its underlying mechanisms in RA. METHODS: The chemical composition of MP extract was analyzed using
PubMed: 41537667Chemical profiling, in vitro antioxidant, membrane stabilizing and antimicrobial properties of wild growing Murraya paniculata from Amarkantak (M.P.).
The excessive usage of antibiotics in humans and veterinary medicine has lead to the emergence of antibiotic resistance and now requires the use of novel antibiotics. There has been increased interest towards plants as source of drugs because of their pharmacological potency and long traditional usage. The aim of the current study was to evaluate bioactive components, antioxidant, and anti-inflammatory activities of the leaf extracts of Murraya paniculata, a plant traditionally used in Indian medicinal system. Evaluations were made for phytochemical analysis, antioxidant, membrane stabilizing,
PubMed: 33963198Comparison of the preventive effects of Murraya exotica and Murraya paniculata on alcohol-induced gastric lesions by pharmacodynamics and metabolomics.
ETHNOPHARMACOLOGICAL RELEVANCE: Multi-source phenomenon is very common for traditional Chinese medicine (TCM). Both Murraya exotica L. (ME) and Murraya paniculata (L.) Jack (MP) are used as the source plants of Murrayae Folium et Cacumen (MFC), a traditional Chinese medicine recorded in Chinese Pharmacopoeia for promoting qi and relieving pain, mainly for the treatment of stomach pain, rheumatism and arthralgia. However, up to now, there has been no comparative study of these two plants on their efficacies and mechanisms, thus, further research is needed to evaluate their similarity and differ
PubMed: 34450164Phytochemical portfolio and anticancer activity of Murraya koenigii and its primary active component, mahanine.
Murraya koenigii, a plant belonging to the Rutaceae family is widely distributed in Eastern-Asia and its medicinal properties are well documented in Ayurveda, the traditional Indian system of medicine. Through systematic research and pharmacological evaluation of different parts of the plant extracts has been shown to possess antiviral, anti-inflammatory, antioxidant, antidiabetic, antidiarrhoeal, antileishmanial, and antitumor activity. In the plant extracts, carbazole alkaloid, mahanine has been identified as the principle bioactive component among several other chemical constituents. Scient
PubMed: 29175114Contexto Científico
En las células, el extracto inhibió la proliferación celular y la migración, además de reducir la expresión de marcadores inflamatorios como iNOS y COX-2.
Seguridad y Precauciones
La seguridad del consumo de Murraya paniculata requiere una vigilancia estricta debido a su compleja composición química y la presencia de compuestos bioactivos. En mujeres embarazadas y lactantes, el uso debe evitarse de forma absoluta; el metilsalicilato presente en la planta actúa como un derivado del ácido salicílico, lo que puede provocar alteraciones en la coagulación fetal y riesgos de cierre prematuro del conducto arterioso durante el desarrollo gestacional. En la lactancia, la transferencia de alcaloides y terpenos a través de la leche materna carece de perfiles de seguridad establecidos en humanos, lo que impide su recomendación. En la población pediátrica, específicamente en niños menores de 12 años, existe un riesgo clínico de síndrome de Reye, debido a la toxicidad de los salicilatos que puede afectar el metabolismo mitocondrial y causar daño hepático y cerebral. En cuanto a las interacciones farmacológicas, la administración de la planta junto con warfarina incrementa significativamente el riesgo de hemorragias, ya que el metilsalicilato posee propiedades antiagregantes que potencian el efecto anticoagulante de la warfarina. La interacción con la metformina es preocupante, pues los alcaloides y saponinas pueden alterar la permeabilidad de las membranas intestinales, afectando la absorción de fármacos y la estabilidad glucémica.
Otras plantas estudiadas para Inflamación
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