Tola para Estrés oxidativo
Parastrephia lucida — 5 estudios científicos revisados
Moderate¿Sirve Tola para estrés oxidativo?
Los flavonoides son un grupo de compuestos vegetales que actúan principalmente como antioxidantes, lo que significa que ayudan a proteger las células del daño causado por los radicales libres.
Compuestos activos involucrados: Apigenina, Distribuido, Flavonoides, Kaempferol, Quercetina, Terpenos, ácido cafeico, ácido ferúlico
Evidencia Científica
Los siguientes estudios han investigado la relación entre Tola y estrés oxidativo:
Inhibition of cyclooxygenase activity by standardized hydroalcoholic extracts of four Asteraceae species from the Argentine Puna.
We determined the anti-inflammatory activity of standardized extracts of four medicinal plant species (Baccharis incarum, B. boliviensis, Chuquiraga atacamensis, Parastrephia lucida) that grow in the Argentine Puna (3800 m above sea level) and that are used to reduce oxidative stress and alleviate gout and arthritic pain. The extracts of plant aerial parts were standardized in terms of total phenolic compounds and flavone/flavanone content and free radical scavenging activity. All extracts showed high phenolic compound concentration (0.5-1.6 mg/mL), mainly flavones and flavonols (0.1-0.8 mg/mL
PubMed: 19738984Evaluation of analgesic activities of tremetone derivatives isolated from the Chilean altiplano medicine Parastrephia lepidophylla.
Parastrephia lepidophylla, family Asteraceae, has ancient use in traditional medicine in the region of Tarapacá, Chile. Bioguided fractionation of extracts of this plant was undertaken in the search for compounds with analgesic and antioxidant activity. Two benzofuran derivatives were isolated as the major components of this plant, identified as tremetone 1 and methoxytremetone 6. Remarkably, neither of these showed antioxidant activity, but tremetone 1 exhibited a morphine-like analgesic property. Reduction of this analgesic effect by naloxone suggests a direct effect on opiate receptors as a
PubMed: 22799089Argentinean Puna Plants with In Vitro Antioxidant and Anti-Inflammatory Activities as a Potential Nutraceutical.
Parastrephia lucida (Compositae), Tessaria absinthioides (Compositae), and Ephedra multiflora (Ephedraceae), three plant species from the Argentinean Puna (3600 m.a.s.l.) were selected for their anti-inflammatory and antioxidant properties to prepare mixtures to evaluate their use as nutraceuticals. Seven binary and ternary herbal mixtures made of ethanol 20% extracts of the selected plant species were prepared (Mixtures A to G), and they were analyzed for their effect on proinflammatory enzymes and their antioxidant activity in two cellular systems and in cell free systems. Toxicity tests wer
PubMed: 31782531Inhibition of pro-inflammatory enzymes by medicinal plants from the Argentinean highlands (Puna).
ETHNOPHARMACOLOGICAL RELEVANCE: Human groups in the Argentinean Andes highlands (Puna) selected native plants as anti-inflammatory agents. The indications of use are mainly to relieve pain, as infusions, ethanolic extracts or plasters. AIM OF THE STUDY: The objective of the study was to assess the effect of hydroalcoholic extracts from native highland plants as anti-inflammatory agents according to the traditional indications of use. The chemical profile of the three most active species was analyzed by HPLC-ESI-MS to get an insight into the constituents and the effects observed according to th
PubMed: 28433637High resolution UHPLC-MS characterization and isolation of main compounds from the antioxidant medicinal plant
High-resolution mass spectrometry is currently used to determine the mass of biologically active compounds in medicinal plants and food and UHPLC-Orbitrap is a relatively new technology that allows fast fingerprinting and metabolomics analysis. Forty-two metabolites including several phenolic acids, flavonoids, coumarines, tremetones and ent-clerodane diterpenes were accurately identified for the first time in the resin of the medicinal plant
PubMed: 29158712Contexto Científico
Estudio sobre la actividad antiinflamatoria y antioxidante en la Puna [PMID 28433637]: Esta investigación utilizó un modelo in vitro para evaluar la capacidad de la planta de inhibir enzimas proinflamatorias como la sPLA2, la lipoxigenasa (LOX) y la hialuronidasa.
Seguridad y Precauciones
El uso de Parastrephia lucida (Tola) requiere una precaución extrema debido a la ausencia de estudios clínicos en humanos que determinen una dosis terapéutica segura o un límite de toxicidad máxima. En el contexto de la gestación y la lactancia, no existe evidencia científica que garantice la ausencia de efectos teratogénicos (daños al desarrollo fetal) o alteraciones en la composición de la leche materna; por lo tanto, su uso está estrictamente contraindicado en mujeres embarazadas y lactantes para evitar riesgos potenciales al feto o al lactante. En la población pediátrica, específicamente en niños menores de 12 años, el uso debe evitarse debido a la inmadurez de sus sistemas enzimáticos hepáticos y renales, lo que podría derivar en una acumulación tóxica de metabolitos no identificados. Respecto a las interacciones farmacológicas, la Tola presenta un riesgo elevado de interacción con la warfarina (anticoagulante) debido a su potencial actividad sobre las vías de los eicosanoides y la inflamación, lo que podría potenciar o alterar la coagulación sanguínea de forma impredecible. Asimismo, existe un riesgo de interacción con la metformina, dado que los componentes fenólicos y flavonoides de la planta podrían alterar la respuesta glucémica. En pacientes que utilizan antihipertensivos, la planta podría interferir con la regulación vascular mediada por la inhibición de la ciclooxigenasa (COX) y la fosfolipasa A2 (sPLA2), alterando la homeostasis de la presión arterial.
Otras plantas estudiadas para Estrés oxidativo
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