Pinellia para Irritación de la mucosa oral y faríngea
Pinellia ternata — 4 estudios científicos revisados
Strong¿Sirve Pinellia para irritación de la mucosa oral y faríngea?
La presencia de cristales de oxalato de calcio en forma de aguja (NCOCs) y lectinas provoca una irritación mecánica y química inmediata en los tejidos blandos de la boca y la garganta al contacto directo.
Compuestos activos involucrados:
Evidencia Científica
Los siguientes estudios han investigado la relación entre Pinellia y irritación de la mucosa oral y faríngea:
A comprehensive review on ethnopharmacological, phytochemical, pharmacological and toxicological evaluation, and quality control of Pinellia ternata (Thunb.) Breit.
ETHNOPHARMACOLOGICAL RELEVANCE: Pinellia ternata tuber (PTT), the dried tuber of Pinellia ternata (Thunb.) Breit., has a long history of use in traditional Chinese medicine for drying dampness, resolving phlegm, down-bearing counterflow to check vomiting and dissipating masses. Modern pharmacology studies have revealed that PTT has diverse pharmacological effects such as antitussive and expectorant, anti-emetic, anti-tumor, and anti-inflammatory effect, etc. AIM OF THE REVIEW: This review aims to provide a critical and comprehensive evaluation on ethnopharmacological uses, chemical constituent
PubMed: 35988838Pinellia ternata lectin induces inflammation through TLR4 receptor and mediates PI3K/Akt/mTOR axis to regulate NF-κB signaling pathway.
Pinellia ternata, a widely used traditional Chinese medicine, contains a strong mucosal irritant that is connected with Pinellia ternata lectin (PTL) in its tubers. The purpose of this study was to explore the mechanisms by which PTL induces inflammation. We found that in RAW264.7 cells, PTL activated the PI3K/Akt/mTOR and NF-κB pathways, which resulted in the release of proinflammatory cytokines. Flow cytometry and laser confocal microscopy analysis showed that FITC-labeled PTL bound to the macrophages' surface. Based on kinetic analyses and protein-protein docking simulations, PTL was shown
PubMed: 36669722A review of traditional and current processing methods used to decrease the toxicity of the rhizome of Pinellia ternata in traditional Chinese medicine.
ETHNOPHARMACOLOGICAL RELEVANCE: The rhizome of Pinellia ternata (Thunb.) Breit, called Pinelliae Rhizoma (PR) and Banxia in Chinese, is a well-known traditional Chinese medicine (TCM) with the functions of "removing dampness-phlegm" and "downbear counterflow and check vomiting". PR has potential toxic effects that can be detoxified by Fuzhi processing (repeated processing using one or multiple adjuvants) with specific adjuvants. AIM OF THE STUDY: This paper aims to provide a summary of traditional and current processing methods used to detoxify PR. MATERIALS AND METHODS: The available referenc
PubMed: 36087845Unveiling terahertz wave stress effects and mechanisms in Pinellia ternata: Challenges, insights, and future directions.
This review aims to elucidate the intricate effects and mechanisms of terahertz (THz) wave stress on Pinellia ternata, providing valuable insights into plant responses. The primary objective is to highlight the imperative for future research dedicated to comprehending THz wave impacts across plant structures, with a specific focus on the molecular intricacies governing root system structure and function, from shoots to roots. Notably, this review highlights the accelerated plant growth induced by THz waves, especially in conjunction with other environmental stressors, and the subsequent altera
PubMed: 38332400Seguridad y Precauciones
La seguridad de Pinellia ternata es un asunto de extrema importancia debido a su perfil toxicológico intrínseco. El rizoma crudo no debe ser administrado por vía oral, ya que contiene componentes altamente irritantes como cristales de oxalato de calcio en forma de aguja (NCOCs) y lectinas (proteínas), los cuales pueden causar irritación severa de la mucosa oral y faríngea, así como efectos sistémicos graves [PMID 36087845]. En cuanto al embarazo y la lactancia, el uso de Pinellia está estrictamente contraindicado. La evidencia científica indica que el rizoma posee toxicidad gestacional y potencial teratogénico (capacidad de causar malformaciones congénitas en el feto) [PMID 36087845]. Debido a que los mecanismos de transferencia de compuestos a través de la placenta y la leche materna no están completamente definidos, el riesgo de daño al desarrollo fetal o neonatal es inaceptablemente alto. No existe una dosis segura establecida para mujeres gestantes o lactantes.
Perfil completo: Ver todos los usos y evidencia de Pinellia →