Plumbago coerulea para Inflamación
Plumbago coerulea — 7 estudios científicos revisados
Preliminary¿Sirve Plumbago coerulea para inflamación?
El segundo eje es la actividad antiinflamatoria y protección pulmonar.
Compuestos activos involucrados: {'name': 'Plumbagina', 'class': '1,4-Naftoquinona'}, {'name': 'Beta-sitosterol', 'class': 'Fitosterol'}, {'name': 'Alcaloides de guanidina', 'class': 'Alcaloide'}, {'name': 'Polisacáridos (WPZP)', 'class': 'Polisacárido'}, Alcaloides, Glucósidos, Plumbagina, Beta-sitosterol, Sitosterol
Evidencia Científica
Los siguientes estudios han investigado la relación entre Plumbago coerulea y inflamación:
Plumbagin ameliorates LPS-induced acute lung injury by regulating PI3K/AKT/mTOR and Keap1-Nrf2/HO-1 signalling pathways.
Acute lung injury (ALI) is a major pathophysiological problem characterized by severe inflammation, resulting in high morbidity and mortality. Plumbagin (PL), a major bioactive constituent extracted from the traditional Chinese herb Plumbago zeylanica, has been shown to possess anti-inflammatory and antioxidant pharmacological activities. However, its protective effect on ALI has not been extensively studied. The objective of this study was to investigate the protective effect of PL against ALI induced by LPS and to elucidate its possible mechanisms both in vivo and in vitro. PL treatment sign
PubMed: 38990057Purification and structural characterization of two polysaccharides with anti-inflammatory activities from Plumbago zeylanica L.
Plumbago zeylanica L., a traditional Chinese medicine, has anti-bacterial and anti-inflammatory effects, and it is critical important to explore the chemical compounds and evaluate their biological actions from the medicinal plant. However, the chemical structure and biological activities of polysaccharides from P. zeylanica. were still poorly understood. In this study, two water-soluble polysaccharides named WPZP-2-1 and WPZP-2-2 were purified from P.
PubMed: 38232876Phytochemical profiling and anti-fibrotic activities of Plumbago indica L. and Plumbago auriculata Lam. in thioacetamide-induced liver fibrosis in rats.
This study aimed at investigating the chemical composition and the hepatoprotective activities of Plumbago indica L. and P. auriculata Lam. LC-MS/MS analyses for the hydroalcoholic extracts of the aerial parts of the two Plumbago species allowed the tentative identification of thirty and twenty-five compounds from P. indica and P.
PubMed: 35701526Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway.
BACKGROUND: Rheumatoid arthritis (RA) is a systemic disease that primarily manifests as chronic synovitis of the symmetric small joints. Despite the availability of various targeted drugs for RA, these treatments are limited by adverse reactions, warranting new treatment approaches. Suberosin (SBR), isolated from Plumbago zeylanica-a medicinal plant traditionally used to treat RA in Asia-possesses notable biological activities. This study aimed to investigate the effects and potential underlying pathways of SBR on RA. METHODS: Tumor necrosis factor-alpha (TNF-α) induced inflammation in RA-deri
PubMed: 39838477Five undescribed guanidine alkaloids from Plumbago zeylanica.
Five undescribed guanidine alkaloids, plumbagines HK (1-4) and plumbagoside E (5), as well as five known analogues (6-10) were isolated from the roots of Plumbago zeylanica. Their structures were established by extensive spectroscopic analyses and chemical methods. In addition, 1-10 were accessed their anti-inflammatory activities by measuring nitric oxide (NO) concentrations in LPS-induced RAW 264.7 cells. However, all compounds especially 1 and 3-5 could not inhibit the secretion of NO but significant increase the secretion of NO. The result reminded us that 1-10 may become potential novel i
PubMed: 37178808Seguridad y Precauciones
La toxicidad de Plumbago coerulea se deriva principalmente de su contenido de plumbagin, un compuesto de la familia de las naftoquinonas con propiedades citotóxicas, es decir, la capacidad de destruir células sanas mediante procesos de estrés oxidativo e interferencia en la división celular. En el periodo de embarazo, el uso de esta planta está estrictamente desaconsejado debido a que el plumbagin puede atravesar la barrera placentaria, interfiriendo con el desarrollo embrionario, lo que representa un riesgo de malformaciones o pérdida gestacional. En la lactancia, no existe evidencia científica que garantice que los metabolitos —sustancias resultantes de la descomposición química de la planta en el organismo— no pasen a la leche materna, lo que pone en riesgo la salud del lactante. Para niños menores de 12 años, la toxicidad es crítica debido a su menor masa corporal y sistemas metabólicos en desarrollo, lo que aumenta el riesgo de una intoxicación sistémica severa. En cuanto a las interacciones medicamentosas, el uso de Plumbago coerulea junto con la warfarina es extremadamente peligroso; el plumbagin puede interferir con el metabolismo hepático (el proceso por el cual el hígado descompone y elimina sustancias), lo que podría elevar los niveles de la warfarina en sangre y provocar hemorragias graves por una alteración en la coagulación. Con la metformina, el riesgo reside en la exacerbación de la irritación de la mucosa gástrica, provocando cuadros de náuseas y diarrea severos.
Otras plantas estudiadas para Inflamación
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