Podocarpus oleifolius para Cáncer
Podocarpus oleifolius — 10 estudios científicos revisados
Preliminary¿Sirve Podocarpus oleifolius para cáncer?
Esto significa que, en un entorno controlado, los compuestos podrían tener un potencial interés en el desarrollo de terapias contra el cáncer, aunque esto requiere validación en organismos complejos.
Compuestos activos involucrados: Fenoles, Flavonoides, Polifenol, Polifenoles, Saponinas, Taninos, Terpenos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Podocarpus oleifolius y cáncer:
Anticancer Activities and Mechanism of Action of Nagilactones, a Group of Terpenoid Lactones Isolated from Podocarpus Species.
Nagilactones are tetracyclic natural products isolated from various Podocarpus species. These lactone-based compounds display a range of pharmacological effects, including antifungal, anti-atherosclerosis, anti-inflammatory and anticancer activities reviewed here. The most active derivatives, such as nagilactones C, E and F, exhibit potent anticancer activities against different cancer cell lines and tumor models. A comprehensive analysis of their mechanism of action indicates that their anticancer activity mainly derives from three complementary action: (i) a drug-induced inhibition of cell p
PubMed: 33034879Matairesinol blunts adverse cardiac remodeling and heart failure induced by pressure overload by regulating Prdx1 and PI3K/AKT/FOXO1 signaling.
BACKGROUND: Pathological cardiac remodeling is a critical process leading to heart failure, characterized primarily by inflammation and apoptosis. Matairesinol (Mat), a key chemical component of Podocarpus macrophyllus resin, exhibits a wide range of pharmacological activities, including anti-hydatid, antioxidant, antitumor, and anti-inflammatory effects. PURPOSE: This study aims to investigate whether Matairesinol alleviate cardiac hypertrophy and remodeling caused by pressure overload and to elucidate its mechanism of action. METHODS: An in vitro pressure loading model was established using
PubMed: 39306883Norditerpenoids and Dinorditerpenoids from the Seeds of Podocarpus nagi as Cytotoxic Agents and Autophagy Inducers.
Nine new norditerpenoids and dinorditerpenoids, 2-oxonagilactone A (1), 7β-hydroxynagilactone D (2), nagilactones K and L (3 and 4), 3β-hydroxynagilactone L (5), 2β-hydroxynagilactone L (6), 3-epi-15-hydroxynagilactone D (7), 1α-chloro-2β,3β,15-trihydroxynagilactone L (8), and 15-hydroxynagilactone L (9), were isolated from the seeds of Podocarpus nagi, along with eight known analogues. The structures of the new compounds were established based on detailed NMR and HRESIMS analysis, as well as from their ECD spectra. The absolute configuration of the known compound 1-deoxy-2α-hydroxynagilactone
PubMed: 28719204Novel Diterpenoids from the Twigs of Podocarpus nagi.
Phytochemical investigation of the twigs of Podocarpus nagi (Podocarpaceae) led to the isolation of two new abietane-type diterpenoids, named 1β,16-dihydroxylambertic acid (1) and 3β,16-dihydroxylambertic acid (2), along with two new ent-pimarane-type diterpenoids, named ent-2β,15,16,18-tetrahydroxypimar-8(14)-ene (3) and ent-15-oxo-2β,16,18-trihydroxypimar-8(14)-ene (4). Their respective structures were elucidated on the basis of spectroscopic analyses, including 1D- and 2D-NMR, IR, CD, and HR-ESI-MS. This is the first time ent-pimarane-type diterpenoids from the genus Podocarpus has been rep
PubMed: 27681713Antimicrobial activity, toxicity and selectivity index of two biflavonoids and a flavone isolated from Podocarpus henkelii (Podocarpaceae) leaves.
BACKGROUND: Different parts of Podocarpus henkelii have been used in many cultures around the world to treat ailments such as cholera, stomach diseases, rheumatism, cancer, canine distemper in dogs and gall sickness in cattle. The aim of this study was to evaluate the biological activity and toxicity of isolated compounds from Podocarpus henkelii after an earlier study indicated a promising activity in crude extracts against viral pathogens of veterinary importance. METHODS: The antibacterial and antifungal activity of two biflavonoids 7, 4', 7", 4"'-tetramethoxy amentoflavone (TMA), isoginkge
PubMed: 25293523Seguridad y Precauciones
La seguridad del consumo de Podocarpus oleifolius en seres humanos es un área con una brecha de conocimiento significativa, ya que actualmente no existen ensayos clínicos controlados que avalen su uso terapéutico seguro en la población general. En relación con el embarazo y la lactancia, la evidencia científica es inexistente; debido a la presencia de metabolitos secundarios complejos como diterpenos y resinas, existe un riesgo teórico de que estos compuestos atraviesen la barrera placentaria o se secreten en la leche materna, lo que podría interferir con el desarrollo embrionario o la salud del lactante. Se recomienda evitar su uso en estas etapas por precaución absoluta. Para niños menores de 12 años, su uso está estrictamente contraindicado, dado que su sistema enzimático hepático y su función renal no están plenamente desarrollados para procesar la carga química de las resinas de esta conífera, lo que podría derivar en una toxicidad sistémica aguda. Respecto a las interacciones medicamentosas, la planta presenta riesgos críticos con la warfarina, ya que sus componentes pueden inhibir o inducir las enzimas del citocromo P450 (específicamente la isoenzima CYP2C9), alterando la coagulación sanguínea y aumentando el riesgo de hemorragias. Con la metformina, la planta podría interferir con los mecanismos de transporte renal, complicando su excreción.
Otras plantas estudiadas para Cáncer
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