Santa María para Estrés oxidativo
Pothomorphe peltata — 11 estudios científicos revisados
Preliminary¿Sirve Santa María para estrés oxidativo?
En estudios de caracterización fitoquímica y actividad antioxidante in vitro, se ha determinado que los extractivos de la planta presentan una alta concentración de compuestos fenólicos.
Compuestos activos involucrados: Alcaloides, Flavonoides, Terpenoides, Terpenos, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Santa María y estrés oxidativo:
4-Nerolidylcatechol from Pothomorphe spp. scavenges peroxyl radicals and inhibits Fe(II)-dependent DNA damage.
The total reactive antioxidant potential (TRAP) and total antioxidant reactivity (TAR) of 4-nerolidylcatechol (4-NC) and methanolic extracts of Pothomorphe umbellata and P. peltata were determined by monitoring the intensity of luminol enhanced chemiluminescence by peroxyl radicals derived from thermolysis of 2,2'-azobis(2-amidinopropane). The highest antioxidant potential was measured in the extract of P. umbellata (TRAP = 97.2 microM) while the highest reactivity was observed in the extract of P. peltata (TAR = 5.0 microM), measured as equivalents of Trolox concentration.
PubMed: 9434614Cytotoxic 4-nerolidylcatechol from Pothomorphe peltata inhibits topoisomerase I activity.
Bioactivity-guided fractionation of the leaf methanolic extract of P. peltata (Piperaceae), using the brine shrimp lethality test, led to the isolation of catechol derivative 4-nerolidylcatechol (4-NC). The methanolic extract was active against crown gall tumour in potato discs, showing a 22% crown gall tumour inhibition (SD = 4%), while 4-NC was cytotoxic against KB tumour cells growth (EC50 = 1.3 micrograms/ml). No interaction with DNA could be observed when tested using the methyl green-DNA (MG-DNA) bioassay. An inhibition in the activity of topoisomerase I using agarose gel electrophoresis
PubMed: 10364848Inhibition of lipid peroxidation and iron (II)-dependent DNA damage by extracts of Pothomorphe peltata (L). Miq.
Leaves of Pothomorphe peltata (L.) Miq. (Piperaceae) are used locally as anti-inflammatory, antipyretic, hepatoprotective and diuretic infusions and to treat external ulcers and local infections in several parts of the Peruvian, Bolivian and Brazilian Amazon region. The antioxidant activity of different extracts of P. peltata was studied using the hydroperoxide-initiated chemiluminescence assay in liver homogenates, and the methanolic extract was found to have the highest antioxidant activity, with an IC50 = 4 micrograms/ml. Aqueous and dichloromethane extracts did not show antioxidant activit
PubMed: 9222409Absence of mutagenicity of Potomorphe umbellata and Potomorphe peltata in the Salmonella/mammalian-microsome mutagenicity assay.
The development of short term tests for measuring the mutagenic activity of genotoxic chemicals has been helpful in increasing security. Natural products from the flora are largely used in popular medicine. Using the Salmonella/mammalian-microsome assay, we investigated the genetic toxicity of two plant species popularly used in malaria treatment, Pothomorphe umbellata and Pothomorphe peltata. The data show the absence of genetic toxicity for both plant species.
PubMed: 3330461Cytotoxicity and antitumoral activity of dichloromethane extract and its fractions from Pothomorphe umbellata.
The cytotoxicity of the dichloromethane crude extract (DCE), obtained from the aerial parts of Pothomorphe umbellata (L.) Miq (Piperaceae), was evaluated against nine human cancer cell lines (MCF-7, NCI-ADR/RES, OVCAR-3, PC-3, HT-29, NCI-H460, 786-O, UACC-62, K-562). The DCE presented antiproliferative activity with good potency against all cell lines at low concentrations (between 4.0 and 9.5 microg/mL) and with selectivity (1.55 microg/mL) for the leukemia cell line (K-652). DCE (100, 200, 300 and 400 mg/kg, ip) was also evaluated in the Ehrlich ascites tumor model. Both the survival number
PubMed: 18545814Seguridad y Precauciones
SEGURIDAD Y PRECAUCIONES (Santa María - Pothomorphe peltata) El uso de la Santa María (Pothomorphe peltata) debe abordarse con precaución, ya que, aunque es una planta ampliamente utilizada en la medicina tradicional de la Amazonia y otras regiones de Latinoamérica, la falta de estudios clínicos exhaustivos en humanos limita la determinación de un margen de seguridad absoluto. Embarazo y Lactancia: No existe evidencia científica suficiente que garantice la inocuidad de esta planta en mujeres gestantes o en periodo de lactancia. Debido al potencial de sus metabolitos secundarios para atravesar la barrera placentaria o excretarse en la leche materna, su uso está contraindicado en estas etapas para evitar riesgos de toxicidad fetal o neonatal no identificados. Niños y Lactantes: Se desaconseja el uso de preparaciones de Santa María en la población pediátrica. Los sistemas metabólicos y de eliminación renal/hepática de los niños son inmaduros, lo que incrementa el riesgo de toxicidad por concentraciones elevadas de compuestos activos. Interacciones con Fármacos: Debido a la presencia de metabolitos de la familia Piperaceae, existe un riesgo teórico de interacciones farmacocinéticas.
Otras plantas estudiadas para Estrés oxidativo
Perfil completo: Ver todos los usos y evidencia de Santa María →