Prunus para Estrés oxidativo
Prunus mahaleb — 7 estudios científicos revisados
Moderate¿Sirve Prunus para estrés oxidativo?
Uso documentado en la medicina tradicional y respaldado por investigación preliminar
Compuestos activos involucrados: Flavonoides, Polifenoles, Ácido ferúlico, Fenoles, Lípido, Tirosinasa, Compuestos fenólicos, Tocoferoles, ácido linoleico, ácidos grasos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Prunus y estrés oxidativo:
Prunus Mahaleb Fruit Extract Prevents Chemically Induced Colitis and Enhances Mitochondrial Oxidative Metabolism via the Activation of the Nrf2 Pathway.
SCOPE: Polyphenols exhibit their antioxidant activity downstream the activation of the nuclear factor erythroid 2-related factor 2 pathway (Nrf2), but the connection between lipid metabolism and the Nrf2 pathway is still unknown. Flavonoid-rich concentrated extract from Prunus mahaleb (mahaleb concentrated fruit extract; MCFE) may act on oxido-reductive homeostasis and hepatic lipid metabolism via Nrf2. METHODS & RESULTS: MCFE ability to enhance the activity of Nrf2-mediated antioxidant/detoxifying enzymes is investigated in liver and colon of BALB/c mice. After a 4-week supplementation, macro
PubMed: 31410984Anti-tyrosinase and antimelanogenic effect of cinnamic acid derivatives from Prunus mahaleb L.: Phenolic composition, isolation, identification and inhibitory activity.
ETHNOPHARMACOLOGICAL RELEVANCE: The traditional use of Prunus species against skin diseases and especially for skin lightning cosmeceutical purposes is widespread in many cultures. Prunus mahaleb L. is a well known food plant and used in the baking industry for flavoring. The fruit kernels (endocarp) are used in India for hyperpigmentation. AIM OF THE STUDY: To investigate the chemical composition with the antimelanogenesis effect of P.
PubMed: 36924865Case Report: Allergic Reactivity to Mahaleb (
BACKGROUND: Mahaleb is an aromatic spice prepared from the fruit stone of the St. Lucie Cherry that is used as a flavoring agent in traditional Turkish and Middle Eastern baking. Immunodiagnostic kits for almond, which are based on polyclonal almond-specific IgG antibodies, have been shown to demonstrate considerable cross-reactivity with mahaleb as was incidentally discovered during a cluster of allergen-related food recalls in 2015. OBJECTIVE: Though acute allergy to almond is somewhat common, allergies to mahaleb have not been previously documented. However, based on antigenic similarity ob
PubMed: 33117599Characterization of white Mahlab (Prunus mahaleb L.) seed oil: a rich source of α-eleostearic acid.
UNLABELLED: Seed oils with high polyunsaturated fatty acid content are used in various industries including the food and pharmaceutical industries. White mahlab (Prunus mahaleb L.) seed was found to contain 31% oil. The oil was highly polyunsaturated and abundant in α-eleostearic (38.32%), oleic (31.29%), and linoleic (22.96%) acids, which together comprised 93.91% of the total fatty acids. The α-eleostearic acid was identified and characterized based on (1)H-NMR, UV, and FTIR spectroscopy. The oil was characterized by a relatively high quantity of tocopherols with γ-tocopherol as the major to
PubMed: 24754875Polyphenolic composition and antioxidant activity of the under-utilised Prunus mahaleb L. fruit.
BACKGROUND: The identification of novel plant-based functional foods or nutraceutical ingredients that possess bioactive properties with antioxidant function has recently become important to the food, nutraceutical and cosmetic industries. This study evaluates the polyphenolic composition, identifies bioactive compounds and assays the total antioxidant capacity of Prunus mahaleb L. fruits collected from different populations and sampling years in the countryside around Bari (Apulia Region, Italy). RESULTS: We identified nine polyphenolic compounds including major anthocyanins, coumaric acid de
PubMed: 26300229Contexto Científico
Los resultados mostraron que la suplementación con MCFE aumentó las defensas antioxidantes en el colon de los ratones y mitigó los signos patológicos de la colitis en comparación con el grupo de control positivo. Este estudio fue de tipo in vitro (utilizando ensayos de tirosinasa de hongo y células de melanoma murino B16F10) para evaluar la antimelanogénesis. mahaleb poseen una potente capacidad para inhibir la enzima tirosinasa.
Seguridad y Precauciones
La seguridad en el uso de Prunus mahaleb es un tema de creciente interés debido a su uso tradicional en la industria alimentaria y su potencial bioactivo. En el caso de mujeres en periodo de embarazo y lactancia, la evidencia científica actual es extremadamente limitada, lo que obliga a mantener una postura de precaución absoluta. No existen estudios clínicos que determinen la seguridad del consumo de extractos de mahaleb en el desarrollo fetal o la transferencia a través de la leche materna. Dado que el mahaleb puede contener compuestos bioactivos que afectan el metabolismo oxidativo y la señalización celular (como se sugiere en la activación de la vía Nrf2), existe un riesgo teórico de interferencia con procesos de desarrollo embrionario. Por tanto, se desaconseja su consumo durante estas etapas. En cuanto a niños menores de 12 años, la falta de estudios de toxicidad pediátrica y la variabilidad en la respuesta metabólica de los infantes hacen que su uso no sea recomendable.
Otras plantas estudiadas para Estrés oxidativo
Perfil completo: Ver todos los usos y evidencia de Prunus →