Rosa para Obesidad y desequilibrio metabólico
Rosa multiflora — 7 estudios científicos revisados
Preliminary¿Sirve Rosa para obesidad y desequilibrio metabólico?
Los compuestos de la planta pueden inhibir la expresión de genes relacionados con la acumulación de lípidos (como PPARγ y SREBP-1c), ayudando a reducir la acumulación de grasa en modelos animales.
Compuestos activos involucrados: Citronelol, Fenoles, Flavonoides, Polifenoles, Quercetina, Terpenoides, Terpenos, ácido elágico, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Rosa y obesidad y desequilibrio metabólico:
Rosa multiflora fructus and its active compound ellagic acid improve depressive-like behaviors in mice via monoamine oxidase inhibition.
Depression is a significant global health challenge, imposing severe social and economic burdens. Rosa multiflora fructus possesses a range of biological properties; however, its role in reducing stress hormone-induced depression remains unclear. This study examined the antidepressant effects of Rosa multiflora fructus extract (RMFE) on corticosterone (CORT)-induced depressive-like behaviors in mice and explored the underlying molecular mechanisms. ICR mice were administered CORT (40 mg/kg/day, i.p.) for 8 weeks to induce depressive-like behaviors. They were then treated with RMFE (100 or 300
PubMed: 40373631Evolution of the biosynthetic pathways of terpene scent compounds in roses.
It is unknown why roses are terpene-rich, what the terpene biosynthetic pathways in roses are, and why only a few rose species produce the major components of rose essential oil. Here, we assembled two high-quality chromosome-level genomes for Rosa rugosa and Rosa multiflora. We also re-sequenced 132 individuals from the F1 progeny of Rosa chinensis and Rosa wichuraiana and 36 of their related species. Comparative genomics revealed that expansions of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) and terpene synthases (TPSs) gene families led to the enrichment of terpenes in rose s
PubMed: 39043188Effects of
BACKGROUND/OBJECTIVES: Obesity is a major cause of metabolic disorders; to prevent obesity, research is ongoing to develop natural and safe ingredients with few adverse effects. In this study, we determined the anti-obesity effects of MATERIALS/METHODS: The anti-obesity effects of KWFD-H01in 3T3-L1 adipocytes and SD rats were examined using various assays, including Oil Red O staining, gene expression analyses, protein expression analyses, and blood biochemical analyses. RESULTS: KWFD-H01 reduced intracellular lipid accumulation and inhibited the mRNA expression of peroxisome proliferator-act
PubMed: 38584817Phytochemical characterization of Rosa multiflora Thunb. (Rosaceae) in Japan and South Korea, with a focus on the bioactive flavonol glycoside 'multiflorin A'.
Dried achene or anthocarpous accessory fruits of Rosa multiflora Thunb., Rosae fructus ("Eijitsu" in Japanese), have been used in clinical practice to improve constipation within traditional Japanese medicine. Recently, it has been claimed that the efficacy of this crude drug is decreasing, and multiflorin A, the purgative component, was not detected within the tested samples. In order to clarify the causes of this issue, we investigated Rosa section Synstylae (Rosaceae), including R. multiflora, growing in Japan and South Korea with a focus on the secondary metabolite, multiflorin A. We recog
PubMed: 30949951Nonglandular prickle formation is associated with development and secondary metabolism-related genes in Rosa multiflora.
Roses are among the most economically important ornamental plants worldwide. But prickles on the stem and leaves cause difficulties for cultivation or inconveniences during harvest and transportation, thus are an undesirable horticultural character. However, little is known about the molecular mechanisms of prickle development. In this study, we sought to develop Rosa multiflora (in the family Rosaceae) as a model plant to study prickle formation. The morphology, structure, and ontogeny of prickles were characterized, and transcriptome analysis of prickly and prickleless R.
PubMed: 34343346Seguridad y Precauciones
La seguridad en el uso de Rosa multiflora es un tema que requiere cautela debido a la falta de estudios clínicos extensos en humanos. En cuanto al embarazo y la lactancia, no existe evidencia científica suficiente que garantice la seguridad del consumo de extractos de esta planta en mujeres gestantes o lactantes. Dado que compuestos como el ácido elágico y otros flavonidos pueden cruzar la barrera placentaria o pasar a la leche materna, y considerando que estudios en modelos animales han mostrado efectos biológicos significativos en el sistema nervioso y metabólico, se recomienda evitar su uso durante estas etapas para prevenir cualquier riesgo de desarrollo fetal o interferencia con el lactante. Para niños menores de 12 años, el uso debe ser estrictamente evitado. Los sistemas fisiológicos en desarrollo son altamente sensibles a las modulaciones neuroquímicas y metabólicas; el uso de sustancias con actividad sobre las monoamino oxidasas (MAO) o efectos sobre el peso corporal podría alterar el crecimiento y el equilibrio hormonal de manera impredecible. En términos de interacciones farmacológicas, se debe tener especial cuidado con los fármacos que afectan el sistema nervioso central.
Perfil completo: Ver todos los usos y evidencia de Rosa →