Salvia para Toxicidad sistémica
Salvia cuspidata — 7 estudios científicos revisados
Preliminary¿Sirve Salvia para toxicidad sistémica?
La presencia de diterpenos activos puede causar una carga metabólica en el hígado y los riñones al intentar procesar compuestos bioactivos no estandarizados.
Compuestos activos involucrados: {'name': 'Ácido carnósico', 'class': 'Diterpeno abietano'}, {'name': 'Carnosol', 'class': 'Diterpeno abietano'}, {'name': 'Ácido ursólico', 'class': 'Triterpeno'}
Evidencia Científica
Los siguientes estudios han investigado la relación entre Salvia y toxicidad sistémica:
An abietane diterpene from Salvia cuspidata and some new derivatives are active against Trypanosoma cruzi.
The Plant Kingdom is an excellent source for obtaining natural compounds with antiprotozoal activity. In the present work, we studied the effect of the diterpene 12-hydroxy-11,14-diketo-6,8,12-abietatrien-19,20-olide (HABTO) obtained from the aerial parts of Salvia cuspidata on Trypanosoma cruzi epimastigotes. This compound was found to inhibit parasite growth even at low concentrations (IC50 5 μg/mL) and with low toxicity on mammalian cells. In addition, this diterpene induced an intense vacuolization within the parasites. In order to obtain analogs with greater lipophilicity, chemical modifi
PubMed: 26525862Chia seeds (Salvia hispanica): health promoting properties and therapeutic applications – a review.
Chia has been known for over 5,500 years. Chia seeds were one of the most important components of the diet of Mayas and Aztecs. The chemical composition and technological properties of chia give the plant a high nutritional potential. Chia is a good source of polyunsaturated fatty acids: omega-3 and omega-6, soluble dietary fiber. It also contains appreciable amount of proteins and phytochemicals.
PubMed: 28646829Salvia miltiorrhiza: Traditional medicinal uses, chemistry, and pharmacology.
Salvia miltiorrhiza Bunge (SM) is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The present review is an up-to-date summary of the published scientific information about the traditional uses, chemical constituents, pharmacological effects, side effects, and drug interactions with SM, i
PubMed: 25835361[Not Available].
Nuruozak (Salvia leriifolia Benth), is a perennial herbaceous plant that is endemic to Iran and has recently been introduced as a medicinal plant. Artificial polyploidy is an efficient method to increase the production of secondary metabolites and can result in a whole spectrum of genetic, molecular and physiological modifications. In order to produce an autotetraploid population of nuruozak, various concentrations of colchicine (0.00, 0.05, 0.10, 0.20 or 0.50 % w/v) were applied to the seeds and shoot apical meristems of young seedlings at the fourth leaf-stage. Microscopic studies, flow cyto
PubMed: 30484613Salvia divinorum: from Mazatec medicinal and hallucinogenic plant to emerging recreational drug.
Salvia divinorum is a sage endemic to a small region of Mexico and has been traditionally used by the Mazatec Indians for divination and spiritual healing. Recently, it has gained increased popularity as a recreational drug, used by adolescents and young adults as an alternative to marijuana and LSD. Salvinorin A, the major active ingredient of the plant, is considered to be the most potent known hallucinogen of natural origin. This review surveys the current state of knowledge on the neurochemical, pharmacokinetic, and pharmacological properties of salvinorin A, the trends and motivation behi
PubMed: 23794315Seguridad y Precauciones
El uso de Salvia (Salvia cuspidata) debe abordarse con extrema precaución debido a la falta de estudios clínicos extensos en humanos que establezcan perfiles de seguridad definitivos. En el contexto de embarazo y lactancia, no existe evidencia científica suficiente que garantice la seguridad del consumo de esta planta; por lo tanto, su uso está contraindicado para mujeres gestantes. El riesgo potencial radica en que compuestos diterpénicos presentes en la especie podrían interferir con procesos hormonales o el desarrollo fetal. En periodos de lactancia, el uso de plantas con actividad biológica activa puede resultar en la transferencia de metabolitos a través de la leche materna hacia el lactante, lo cual podría alterar el desarrollo neurológico o fisiológico del bebé. Para niños menores de 12 años, el uso no se recomienda bajo ninguna circunstancia, ya que los sistemas metabólico, renal y hepático en desarrollo son altamente sensibles a los diterpenos y otros metabolitos secundarios que podrían causar toxicidad sistémica o efectos neurovegetativos impredecibles. En cuanto a las interacciones farmacológicas, la Salvia cuspidata podría interactuar con la warfarina (anticoagulantes) debido a posibles efectos sobre la agregación plaquetaria, aumentando el riesgo de hemorragias.
Otras plantas estudiadas para Toxicidad sistémica
Perfil completo: Ver todos los usos y evidencia de Salvia →