Sen para laxative
Senna alexandrina — 15 estudios científicos revisados
Preliminary¿Sirve Sen para laxative?
La investigación científica ha explorado el potencial de Sen (Senna alexandrina) en relación con laxative. Se han identificado 15 estudios relevantes que examinan esta relación.
Compuestos activos involucrados: Fenoles, Flavonoides, Glucósidos, Polifenoles
Evidencia Científica
Los siguientes estudios han investigado la relación entre Sen y laxative:
Functional characterization of two distinct classes of NADPH-cytochrome P450 reductases in Senna alexandrina Mill.
BACKGROUND: Senna alexandrina Mill., an important medicinal plant of Fabaceae family, is famous for its laxative properties which are mainly due to the presence of sennosides (anthraquinone glycosides). However, the complete biosynthetic pathway of sennosides in Senna is not yet fully understood. Cytochrome P450 monooxygenases (CYPs), which are heme-containing enzymes are supposed to play key roles in sennoside biosynthesis. Cytochrome P450 reductases (CPRs) are essential for the activity of CYPs, as they function as their redox partners. However, CPRs in Senna have not yet been characterized
PubMed: 40366465Senna: As immunity boosting herb against Covid-19 and several other diseases.
INTRODUCTION: A novel coronavirus outbreak in China (SARS-CoV-2) which began in December 2019, was proven major threat to global health. However, several results from clinical practices indicate that herbal medicine plays an important role in the prevention of COVID-19, which brings new hope for its treatment. The objective of this study is to check the effectivity of senna (Senna alexandrina Mill.) as an immunity-boosting herb against Covid-19 and several other diseases. METHOD: The literature search was carried out using scientific databases comprising of Scopus, Science Direct, PubMed, Coch
PubMed: 36644449Screening for novel plant sources of prenyloxyanthraquinones: Senna alexandrina Mill. and Aloe vera (L.) Burm. F.
As a continuation of our ongoing studies aimed to reveal the presence of oxyprenylated anthraquinones in plants claimed to have a laxative effect, in this article, we describe the extraction and HPLC separation of madagascin (3-isopentenyloxyemodin) and 3-geranyloxyemodine from dried leaves and fruits of Senna alexandrina Mill. (Leguminosae) and leaves and gel of Aloe vera (L.) Burm. F. (Xanthorrhoeaceae). Both compounds are described herein for the first time as components of extracts of the title plants.
PubMed: 25342202Photostability of sennosides and their aglycones in solution.
INTRODUCTION: Sennosides are the main active constituents of the dried leaves and/or pods of Senna alexandrina Mill. that are used as laxatives. A hypothesis is that aglycones are formed during the degradation of sennosides. However, it is unknown, whether this happens under visible light exposure and how photosensitive sennosides behave in solution. OBJECTIVES: Pure anthraquinone glycosides were tested on their behaviour during sample preparation in the lab under visible light exposure in dependence on the instability of the solvent.
PubMed: 38198752Laxative activities of Cassia sieberiana and Senna obtusifolia.
BACKGROUND: The root and stem bark of Cassia sieberiana DC. (Caesalpiniaceae) and the root of Senna obtusifolia (Linn) Irwin and Barneby (Caesalpiniaceae), used for constipation in Nigeria, were assayed for laxative properties in male albino rats using the official senna leaf (Senna alexandrina Mill. family Caesalpiniaceae) as the reference standard. This is with a view to finding alternative laxative drug to official senna which is presently being imported into Nigeria from the United Kingdom. MATERIALS AND METHODS: The mean percentage of wet faeces in rats, an indication of laxative activity
PubMed: 25392579Seguridad y Precauciones
La seguridad del uso de Senna alexandrina debe abordarse con extrema cautela debido a su potente actividad farmacológica como laxante estimulante, mediada principalmente por los senósidos (glucósidos antraquinónicos). En el contexto del embarazo y la lactancia, el uso de senna está contraindicado. No existe evidencia suficiente que garantice la inocuidad de los senósidos a través de la barrera placentaria, y la estimulación del peristaltismo intestinal puede provocar contracciones uterinas no deseadas, lo que incrementa el riesgo de aborto o parto prematuro. Durante la lactancia, los componentes activos pueden excretarse en la leche materna, pudiendo causar diarrea severa y desequilibrios electrolíticos en el lactante. Para niños menores de 12 años, su uso debe ser estrictamente supervisado por un profesional de la salud; la administración de dosis laxantes en infantes puede derivar en una deshidratación crítica y pérdida de sales minerales esenciales. En cuanto a las interacciones farmacológicas, la senna puede interferir con la warfarina (un anticoagulante), ya que la diarrea inducida puede alterar la absorción sistémica de medicamentos, modificando su eficacia y aumentando el riesgo de hemorragias o trombosis.
Otras plantas estudiadas para laxative
Perfil completo: Ver todos los usos y evidencia de Sen →