Smilax domingensis para Estrés oxidativo renal
Smilax domingensis — 6 estudios científicos revisados
Preliminary¿Sirve Smilax domingensis para estrés oxidativo renal?
Se ha observado en especies del género que pueden activar la vía de señalización Nrf2/HO-1, lo que promueve la expresión de enzimas antioxidantes para mitigar el daño celular y la apoptosis inducida por agentes nefrotóxicos.
Compuestos activos involucrados: Alcaloides, Flavonoides, Saponinas, Terpenos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Smilax domingensis y estrés oxidativo renal:
Estrogenic effects of herbal medicines from Costa Rica used for the management of menopausal symptoms.
OBJECTIVE: Outcomes from the Women's Health Initiative have demonstrated adverse effects associated with hormone therapy and have prioritized the need to develop new alternative treatments for the management of menopause and osteoporosis. To this end, we have been investigating natural herbal medicines used by Costa Rican women to manage menopausal symptoms. METHODS: Seventeen plant species were collected and extracted in Costa Rica. To establish possible mechanisms of action and to determine their potential future use for menopause or osteoporosis, we investigated the estrogenic activities of
PubMed: 19424091Smilax glabra roxb. alleviates cisplatin-induced acute kidney injury in mice by activating the Nrf2/HO-1 Signalling Pathway.
BACKGROUND: Owing to its remarkable efficacy, cisplatin (CDDP) is widely used as a chemotherapeutic drug in clinical cancer treatment; however, its severe nephrotoxicity often leads to acute kidney injury (AKI), in turn adversely affecting patient treatment and quality of life. Smilax glabra Roxb. (TFL), a Chinese herbal medicine, has various pharmacological effects, including antitumour, anti-inflammatory, and antioxidant activities, with the antioxidant activity being of useful in the detoxification of heavy metal toxicity. AIM: This study aimed to investigate, for the first time, the nephro
PubMed: 40043544Selected herbals and human exercise performance.
Herbs have been used throughout history to enhance physical performance, but scientific scrutiny with controlled clinical trials has only recently been used to study such effects. The following herbs are currently used to enhance physical performance regardless of scientific evidence of effect: Chinese, Korean, and American ginsengs; Siberian ginseng, mahuang or Chinese ephedra; ashwagandha; rhodiola; yohimbe; CORDYCEPS: fungus, shilajit or mummio; smilax; wild oats; Muira puama; suma (ecdysterone); Tribulus terrestris; saw palmetto berries; beta-sitosterol and other related sterols; and wild
PubMed: 10919969Manshenkang granules alleviate fibrosis in chronic renal failure rats by regulating the PDE4b/cAMP pathway.
ETHNOPHARMACOLOGICAL RELEVANCE: Manshenkang granules (MSKG) is a traditional Chinese medicinal formula used to treat chronic renal failure, comprising Rheum tanguticum Maxim. ex Balf., Salvia miltiorrhiza Bunge, Citrus × aurantium L., Codonopsis pilosula (Franch.) Nannf., Polygonatum cyrtonema Hua, Smilax glabra Roxb., Ostrea rivularis Gould, and Glycyrrhiza uralensis Fisch. However, their efficacies and mechanisms of action require further investigation. AIM OF THE STUDY: This study explored the role and underlying mechanisms of MSKG in alleviating adenine-induced renal fibrosis in chronic re
PubMed: 39961423Estrogenic and anti-estrogenic compounds from the Thai medicinal plant, Smilax corbularia (Smilacaceae).
From the rhizomes of Smilax corbularia Kunth. (Smilacaceae), 11 compounds, (2R,3R)-2″-acetyl astilbin, (2R,3R)-3″-acetyl astilbin, (2R,3R)-4″-acetyl astilbin, (2R,3R)-3″-acetyl engeletin, (2R,3S)-4″-acetyl isoastilbin, 2-(4-hydroxyphenyl)-3,4,9,10-tetrahydro-3,5-dihydroxy-10-(3,4-dihydroxyphenyl)-(2R,3R,10R)-2H,8H-benzo [1,2-b:3,4-b'] dipyran-8-one, 2-(4-hydroxyphenyl)-3,4,9,10-tetrahydro-3,5-dihydroxy-10-(3,4-dihydroxyphenyl)-(2R,3R,10S)-2H, 8H-benzo [1,2-b:3,4-b'] dipyran-8-one, 3,4-dihydro-7-hydroxy-4-(3,4-dihydroxyphenyl)-5-[(1E)-2-(4-hydroxyphenyl) ethenyl]-2H-1-benzopyran-2-one, 3,4-dihy
PubMed: 21315392Seguridad y Precauciones
El uso de Smilax domingensis requiere una precaución extrema debido a su actividad biológica compleja, especialmente en relación con su potencial actividad hormonal. En mujeres embarazadas y en periodo de lactancia, el consumo de esta planta está estrictamente contraindicado. La evidencia científica sugiere que extractos de Smilax pueden actuar como moduladores de los receptores de estrógeno (actuando como agonistas parciales o antagonistas), lo que podría interferir con el equilibrio endocrino necesario para el desarrollo fetal o la producción de leche materna. No existen estudios que garanticen la ausencia de transferencia de metabolizations esteroidales a través de la leche. En niños menores de 12 años, su uso no debe realizarse debido a la falta de datos sobre la seguridad en sistemas endocrinos en desarrollo y el riesgo de interferencia con la maduración hormonal natural. En cuanto a interacciones farmacológicas, se debe evitar la administración concomitante con warfarina y otros anticoagulantes, ya que las saponinas esteroidales presentes en el género Smilax pueden alterar la respuesta de la coagulación sanguínea.
Otras plantas estudiadas para Estrés oxidativo renal
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