Styrax ovatus para Interacción farmacológica con anticoagulantes
Styrax ovatus — 5 estudios científicos revisados
Strong¿Sirve Styrax ovatus para interacción farmacológica con anticoagulantes?
Inhibición de la enzima citocromo P450 3A4 (CYP3A4) en el hígado, lo que altera la degradación de fármacos como la warfarina [PMID 32739573, PMID 36110541].
Compuestos activos involucrados: Cinamato, Warfarina, ácido, ácido oleanólico
Evidencia Científica
Los siguientes estudios han investigado la relación entre Styrax ovatus y interacción farmacológica con anticoagulantes:
Chemical Constituents and Their Biological Activities from Genus
Plants from the genus
PubMed: 37513954Styrax is the largest genus of the family Styracaceae, with about 130 species distributed across America, Europe, and Southeast Asia. The oleo-resin of these woody shrubs, called Styrax benzoin, has a long tradition of use as incense and in therapeutics, which has stimulated research and industrial applications. Many studies have been carried out on the biological applications of different Styrax species, but some gaps still remain to be filled, particularly regarding the phenology and the biological activity and application in different fields. Hence, this review gathers updated and valuable
PubMed: 40094721Safety evaluation of styrax liquidus from the viewpoint of genotoxicity and mutagenicity.
ETHNOPHARMACOLOGICAL RELEVANCE: Styrax liquidus is a resinous exudate (balsam) obtained from the wounded trunk of the Liquidambar orientalis Mill. (Hamamelidaceae). Styrax has been used for treatment of various ailments in Turkish folk medicine such as skin problems, peptic ulcers, nocturnal enuresis, parasitic infections, antiseptic or as expectorant. AIM OF STUDY: In spite of frequent use of styrax in Turkish folk medicine as well as once as a stabilizer in perfumery industry, negative reports have been noticed by the international authority for restriction its use based on some limited evid
PubMed: 27737816Antinociceptive effects of flower extracts and the active fraction from Styrax japonicus.
ETHNOPHARMACOLOGICAL RELEVANCE: Flowers from Styrax japonicus sieb. et Zucc. have been used as a Chinese folk medicine to alleviate pain such as toothache and sore throat. AIM OF THE STUDY: To testify the analgesic effect of flowers from Styrax japonicus, analyze components of the active fraction, and investigate the mechanism of analgesia. MATERIALS AND METHODS: Flower extracts were obtained by ethanol, petroleum ether and hydrodistillation extraction.
PubMed: 34715297Overview of Covid-19; its prevention and management in the light of Unani medicine.
Since December 2019, a respiratory pandemic named as coronavirus disease 2019 (Covid-19) caused by a new coronavirus named as SARS-CoV-2, has taken the world by storm. The symptoms are fever, malaise, and cough which resolve in a few days in most cases; but may progress to respiratory distress and organ failure. Transmission is through droplet infection or fomites, but other modes such as airborne transmission and oro-fecal transmission are also speculated. Research is underway to develop effective vaccines and medicines for the disease. In such a scenario, we present the measures described in
PubMed: 32334163Seguridad y Precauciones
La seguridad en el uso de Styrax ovatus es un tema de extrema importancia debido a su complejidad bioquímica y su capacidad de interacción con procesos fisiológicos humanos. En relación con el embarazo y la lactancia, no existen estudios clínicos definitivos que garanticen la inocuidad en mujeres gestantes; por lo tanto, se debe evitar su uso durante el periodo de gestación y la lactancia para prevenir riesgos potenciales al desarrollo fetal o la transferencia de compuestos bioactivos a través de la leche materna. Para la población infantil, específicamente menores de 12 años, el uso no está recomendado debido a la falta de datos sobre la toxicidad crónica y el desarrollo neurológico en etapas tempranas. Respecto a las interacciones farmacológicas, el Styrax presenta un riesgo crítico de interacción con la warfarina (un anticoagulante) y otros fármacos metabolizados por el sistema enzimático del hígado. Se ha demostrado que constituyentes de Styrax, como el ácido oleanónico, actúan como inhibidores potentes de la enzima CYP3A4 [PMID 32739573]. La inhibición de la CYP3A4 puede elevar peligrosamente los niveles plasmáticos de medicamentos que dependen de esta vía, aumentando el riesgo de toxicidad o efectos adversos graves.
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