Trifolium para Sofocos (bochornos) menopáusicos
Trifolium pratense — 10 estudios científicos revisados
Moderate¿Sirve Trifolium para sofocos (bochornos) menopáusicos?
Las isoflavonas presentes en el trébol rojo pueden modular los receptores de estrógeno, ayudando a estabilizar las fluctuaciones térmicas asociadas con la deficiencia de estrógenos durante la menopausia.
Compuestos activos involucrados: Biochanina, Cumarinas, Fitoestrógeno, Flavonoides, Formononetina, Genisteína, Isoflavonas, Trébol
Evidencia Científica
Los siguientes estudios han investigado la relación entre Trifolium y sofocos (bochornos) menopáusicos:
Evaluation of Clinical Meaningfulness of Red Clover (
The meta-analysis presented in this article covered the efficacy of red clover isoflavones in relieving hot flushes and menopausal symptoms in perimenopausal and postmenopausal women. Studies were identified by MEDLINE (PubMed), Embase, and the Cochrane Library searches. The quality of the studies was evaluated according to Cochrane criteria. A meta-analysis of eight trials (ten comparisons) demonstrated a statistically significant reduction in the daily incidence of hot flushes in women receiving red clover compared to those receiving placebo: weighted mean difference (WMD-weighted mean diffe
PubMed: 33920485Trifolium pratense isoflavones in the treatment of menopausal hot flushes: a systematic review and meta-analysis.
OBJECTIVE: To critically assess the evidence of supplements containing Trifolium pratense (red clover) isoflavones in the reduction of hot flush frequency in menopausal women. DATA SOURCES: Systematic literature searches were performed in (Medline (1951 - April 2006), Embase (1974 - April 2006), CINAHL (1982 - April 2006), Amed (1985 - April 2006) and The Cochrane Library (Issue 2, 2006). Reference lists located were checked for further relevant publications. Experts in the field and manufacturers of identified products were contacted for unpublished material. No language restrictions were imp
PubMed: 17239573Effects of red clover (Trifolium pratense) isoflavones on the lipid profile of perimenopausal and postmenopausal women-A systematic review and meta-analysis.
AIM: The aim of this systematic review and meta-analysis was to clarify the effect of a specific standardised extract of red clover (Trifolium pratense) on the lipid profile of perimenopausal and postmenopausal women. METHODS: Medline (PubMed), EMBASE, and Cochrane Library electronic databases were searched for papers in English reporting randomized controlled trials published up to 2017. Reference lists from those papers were checked for further relevant publications. Studies were identified and reviewed for their eligibility for inclusion in this review. The changes from baseline in the leve
PubMed: 31883666Red clover (Trifolium pratense) for menopausal women: current state of knowledge.
OBJECTIVE: Red clover (Trifolium pratense) extracts are becoming increasingly popular, primarily for the treatment of menopausal symptoms. Although promoted as a phytoestrogen source similar to soybeans, red clover is a medicinal herb, not a food, and traditionally has not been used long-term. We sought to review the scientific literature for this newer use. DESIGN: Medline was searched for controlled trials of red clover (Trifolium pratense), and other sources were searched for other studies and abstracts. RESULTS: Two double-blind placebo-controlled trials found no beneficial effects of red
PubMed: 11528359A review of effective herbal medicines in controlling menopausal symptoms.
BACKGROUND: Acute menopausal syndrome especially hot flashes, is one of the most common gynecological problems during menopause. Due to the side effects of hormone therapy, herbal and complementary medicines are always of immense interest to people in the treatment and management of the symptoms and complications of menopause. OBJECTIVE: The aim of this study was to investigate the mechanisms and effects of medicinal plants employed in the treatment of menopausal symptoms. METHODS: This review article was carried out by examining clinical trial studies between the period of 1994 and 2016. The
PubMed: 29403626Seguridad y Precauciones
El uso de Trifolium pratense (trébol rojo) requiere una vigilancia clínica estricta debido a su contenido de isoflavonas, que actúan como fitoestrógenos (compuestos vegetales que imitan la estructura y función de los estrógenos humanos). En el contexto de embarazo y lactancia, el uso de este extracto está contraindicado. Debido a su actividad hormonal, existe el riesgo de que las isoflavonas interfieran con el desarrollo endocrino fetal o afecten la composición hormonal de la leche materna, lo que podría alterar el desarrollo sexual del lactante. No existen datos suficientes que garanticen la seguridad en estos periodos, por lo que se debe evitar su consumo. Para niños menores de 12 años, el uso no está recomendado; la manipulación de los ejes hormonales en etapas de crecimiento crítico mediante fitoestrógenos puede tener consecuencias impredecibles en la maduración puberal y el desarrollo neuroendocrino. En cuanto a interacciones farmacológicas, el riesgo principal radica en su efecto sobre la coagulación y el control glucémico.
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