Tulbaghia para Actividad antifúngica
Tulbaghia violacea — 5 estudios científicos revisados
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El extracto de los rizomas de la planta inhibe la síntesis de ergosterol al afectar la enzima oxidosqualene cyclase, lo que debilita la integridad de la membrana celular de hongos como Aspergillus flavus [PMID 34100987].
Compuestos activos involucrados: Antocianinas, Fenoles, Flavonoides, Polifenoles, Saponinas, Terpenos, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Tulbaghia y actividad antifúngica:
Tulbaghia violacea (Harv) Exerts its Antifungal Activity by Reducing Ergosterol Production in Aspergillus flavus.
Opportunistic infections in immunosuppressed patients have led to an increase in fungal infections, with Aspergillus being one of the main causative agents. Medicinal plants exhibiting antifungal activity have the potential to be used as chemotherapeutic agents. However, often their mechanisms of action are not fully researched. Tulbaghia violacea exhibits antifungal activity towards Candida, Aspergillus flavus and Aspergillus parasiticus but its mode of action has only recently begun to be investigated. This study aimed to ascertain the effect of T.
PubMed: 34100987Unravelling potential biomedical applications of the edible flower Tulbaghia violacea.
Traditionally, edible flowers have been used as foods and for therapeutic purposes, today they have gained importance due to their bioactive compounds such as flavonols, anthocyanins or other phenolic compounds, which give them potential for biomedical applications. This work evaluated a methanolic extract of Tulbaghia violacea. Eleven individual phenolic compounds were found and quantified by mass spectrometry in the extract. Antioxidant activity tests (TEAC, FRAP and DPPH) and other characterization parameters were assayed (total phenolic content and total flavonoid content). In vitro studie
PubMed: 35094882Tulbaghia violacea Harv. plant extract affects cell wall synthesis in Aspergillus flavus.
AIMS: This study investigates the effect that aqueous extracts of Tulbaghia violacea Harv. harbouring plant saponins, phenolics and tannins have on Aspergillus flavus β-(1,3) glucan and chitin synthesis. METHODS AND RESULTS: Aspergillus flavus was treated with various subinhibitory concentrations of an aqueous T. violacea plant extract and the β-(1,3) glucan and chitin content was determined together with glucan synthase and chitin synthase production respectively. CONCLUSIONS: The aqueous extract caused a significant decline (P < 0·05) in β-glucan production in A.
PubMed: 28132403Effects of light intensities and varying watering intervals on growth, tissue nutrient content and antifungal activity of hydroponic cultivated
Optimization of the quality and quantity of medicinal materials during cultivation could improve the value of medicinal plants. Light intensity and water availability affect physiological processes and growth of plants.
PubMed: 32455173Aqueous extracts of Tulbaghia violacea inhibit germination of Aspergillus flavus and Aspergillus parasiticus conidia.
Aspergillus flavus and Aspergillus parasiticus are important plant pathogens and causal agents of pre- and postharvest rots of corn, peanuts, and tree nuts. These fungal pathogens cause significant crop losses and produce aflatoxins, which contaminate many food products and contribute to liver cancer worldwide. Aqueous preparations of Tulbaghia violacea (wild garlic) were antifungal and at 10 mg/ml resulted in sustained growth inhibition of greater than 50% for both A. flavus and A. parasiticus.
PubMed: 21669082Seguridad y Precauciones
La seguridad en el uso de Tulbaghia violacea es un área que requiere extrema precaución debido a la falta de estudios clínicos extensos en humanos que establezcan límites de seguridad terapéutica. En el caso de mujeres embarazadas o en periodo de lactancia, el uso de esta planta está estrictamente desaconsejado. No existe evidencia científica suficiente que garantice que los compuestos bioactivos, como los flavonoides o los compuestos fenólicos mencionados en estudios de caracterización, no atraviesen la barrera placentaria o se secreten en la leche materna. Dado que la planta ha mostrado actividad citotóxica (capacidad de destruir células) en líneas celulares cancerígenas en entornos de laboratorio [PMID 32737339], existe un riesgo teórico de interferencia con el desarrollo celular fetal o alteraciones en el crecimiento del lactante. En niños menores de 12 años, la seguridad no puede ser establecida; sus sistemas metabólicos y renales están en desarrollo, lo que podría resultar en una toxicidad impredecible ante la ingesta de extractos concentrados. Respecto a las interacciones farmacológicas, la presencia de compuestos con actividad biológica significativa sugiere riesgos críticos.
Otras plantas estudiadas para Actividad antifúngica
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