Sábila para Cicatrización de heridas

Current Research on Aloe-Derived Extracellular Vesicles in Injury Repair.

In recent years, plant-derived extracellular vesicle-like nanoparticles have garnered significant interest as promising therapeutic agents and delivery vehicles, owing to their biocompatibility and multifaceted bioactivity. Among these, extracellular vesicles derived from Aloe species (A-EVs) have shown considerable potential in promoting tissue repair. However, a consolidated overview linking their physicochemical properties to in vivo reparative functions and clinical translatability is still lacking. This review systematically summarizes current methods for isolating and characterizing A-EV

Aloe-emodin microemulsion gel for diabetic wounds: optimizing surfactant-polymer synergy for effective wound management.

AIM: The present study aimed to develop and optimize an Aloe-emodin-loaded microemulsion gel (AMEG) to improve topical delivery, bioavailability, and therapeutic efficacy for diabetic wound healing. MATERIALS AND METHODS: AMEG was formulated using a D-optimal mixture design, employing Capryol 90 as the oil phase, Labrasol and Tween 80 as surfactants, and Transcutol P as the co-surfactant. The optimized microemulsion was incorporated into a konjac glucomannan (KGM) gel matrix to enhance skin adherence and wound-healing potential. The formulation was characterized for droplet size, clarity, in v

Skin injury is a major problem threatening human physical and mental health, and how to promote wound healing has been the focus. Developing new wound dressings is an important strategy in skin regeneration.

Aloe vera polysaccharides facilitate diabetic wound healing by promoting macrophage M(2) polarization through inhibition of NLRP3 inflammasome activation.

BACKGROUND: Diabetic wound healing impairment poses a serious threat to patient health, underscoring the urgent need for effective therapies. Aloe polysaccharides (APs), one of the main bioactive components of Aloe vera, have been reported to exhibit diverse biological activities, including antibacterial, antioxidant, anti-obesity, and anti-tumor effects. However, their role in diabetic wound repair remains unclear, limiting its translational potential. PURPOSE: This study aims to clarify the therapeutic effect and specific mechanism of APs on diabetic wound healing. STUDY DESIGN AND METHODS:

Natural Extracts in Skin Repair and Wound Healing: Phytochemical Mechanisms and Dermopharmaceutical Perspectives.

BACKGROUND: Skin repair and skin wound healing are tightly regulated biological processes that require coordinated control of inflammation, redox homeostasis, angiogenesis, and tissue remodelling. In this context, natural extracts are increasingly recognized as sources of chemically diverse phytochemicals capable of modulating defined molecular signalling pathways that govern cutaneous repair. METHODS: This review provides a mechanism-informed synthesis of current evidence by examining representative botanical sources, including Aloe vera, Centella asiatica, Curcuma longa, Calendula officinali