Palo brasil para Actividad antiinflamatoria
Caesalpinia echinata — 8 estudios científicos revisados
Preliminary¿Sirve Palo brasil para actividad antiinflamatoria?
La investigación científica ha explorado el potencial de Palo brasil (Caesalpinia echinata) en relación con actividad antiinflamatoria. Se han identificado 8 estudios relevantes que examinan esta relación.
Compuestos activos involucrados: {'name': 'Flavonoides', 'class': 'fitoquímico'}, {'name': 'Terpenos', 'class': 'fitoquímico'}, {'name': 'Saponinas', 'class': 'fitoquímico'}, {'name': 'Alcaloides', 'class': 'fitoquímico'}, Alcaloides, Brazilina, Distribuido, Flavonoides, Saponina, Saponinas, Terpenos, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Palo brasil y actividad antiinflamatoria:
Bioengineering of an elastase inhibitor from Caesalpinia echinata (Brazil wood) seeds.
Protease inhibitors have been widely used in several therapeutic applications such as in the treatment of bleeding disorders, hypertension, cancer and pulmonary diseases. In a previous work, we demonstrated that a Kunitz-type serine protease inhibitor isolated from the seeds of Caesalpinia echinata (CeEI) exhibits pharmacological potential in lung inflammatory diseases in which neutrophil elastase plays a crucial role. However, an important challenge in the use of natural products is to ensure a commercially viable production. In this work, we report the cloning, expression and purification of
PubMed: 33321445Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema.
Acute lung injury (ALI) is characterized by neutrophil infiltration and the release of proteases, mainly elastase (NE), cathepsin G (Cat G) and proteinase 3 (PR3), which can be controlled by specific endogenous inhibitors. However, inhibitors of these proteases have been isolated from different sources, including plants. For this study, CeEI, or Caesalpinia echinata elastase inhibitor, was purified from C. echinata (Brazil-wood) seeds after acetone fractionation, followed by ion exchange and reversed phase chromatographic steps. Characterization with SDS-PAGE, stability assays, amino acid sequ
PubMed: 24140156Evaluation of antioxidant and antiangiogenic properties of caesalpinia echinata extracts.
Natural products contain important combinations of ingredients, which may to some extent help to modulate the effects produced by oxidation substrates in biological systems. It is known that substances capable of modulating the action of these oxidants on tissue may be important allies in the control of neovascularization in pathological processes. The aim of this study was to evaluate the antioxidant and antiangiogenic properties of an ethanol extract of Caesalpinia echinata. The evaluation of antioxidant properties was tested using two methods (DPPH inhibition and sequestration of nitric oxi
PubMed: 24563668Protease Inhibitors Extracted from
Inflammation is an essential process in many pulmonary diseases in which kinins are generated by protease action on kininogen, a phenomenon that is blocked by protease inhibitors. We evaluated kinin release in an
PubMed: 28044105Disclosing the involvement of proteases in an eczema murine animal model: Perspectives for protease inhibitor-based therapies.
Eczema is a skin condition characterized by itchy and inflammatory patches. The accumulation of neutrophils and the imbalance between enzymes and their inhibitors appears to be related to this condition. We proposed a neutrophil elastase (NE)-based eczema model in mice in order to verify histopathological features as well as the expression and activity of proteases and inhibitors. Mice skins were topically administered with human NE (0-2 pmol/cm
PubMed: 34896570Seguridad y Precauciones
La seguridad en el uso de productos derivados de Paubrasilia echinata (Palo brasil) es un tema de extrema cautela debido a la falta de estudios clínicos rigurosos en humanos que establezcan una dosis terapéutica segura. No existe una dosis máxima establecida por organismos de salud internacionales, lo que implica que cualquier exposición debe considerarse de alto riesgo. En cuanto al embarazo y la lactancia, el uso de extractos de esta planta está estrictamente contraindicado; no hay evidencia científica que garantice la ausencia de efectos teratogénicos (malformaciones fetales) o toxicidad sistémica que pueda atravesar la barrera placentaria. Durante la lactancia, la presencia de compuestos fenólicos y la brazilina podría excretarse en la leche materna, con riesgos potenciales de toxicidad para el lactante cuyo sistema metabólico es inmaduro. Para niños menores de 12 años, el uso debe evitarse por completo, ya que sus órganos en desarrollo son altamente susceptibles a compuestos químicos complejos y la toxicidad hepática o renal podría ser irreversible. En términos de interacciones farmacológicas, se debe tener especial cuidado con la warfarina y otros anticoagulantes, dado que los compuestos de la familia Fabaceae pueden alterar la cascada de coagulación o la actividad enzimática del citocromo P450, incrementando el riesgo de hemorragias.
Otras plantas estudiadas para Actividad antiinflamatoria
Perfil completo: Ver todos los usos y evidencia de Palo brasil →