Centella para Cicatrización de heridas
Centella asiatica — 10 estudios científicos revisados
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Estimula la angiogénesis y la proliferación de fibroblastos a través de sus triterpenos para regenerar el tejido dañado.
Compuestos activos involucrados: Apigenina, Estigmasterol, Flavonoides, Quercetina, Rutina, Saponinas, Terpenos, β-sitosterol, Aceite esencial, Asiaticósido, Madecassosido, Sitosterol
Evidencia Científica
Los siguientes estudios han investigado la relación entre Centella y cicatrización de heridas:
Therapeutic potential of Asiaticoside in wound healing after endoscopic submucosal dissection (ESD).
CONTEXT: Endoscopic submucosal dissection (ESD) is the standard treatment for early gastrointestinal cancers but is often complicated by delayed healing and stenosis. Current therapies like proton pump inhibitors primarily suppress acid without actively promoting mucosal regeneration. Asiaticoside (AS), a triterpenoid from Centella asiatica, shows promise in tissue repair. OBJECTIVE: This review evaluates the therapeutic potential of AS for ESD-induced wound healing, focusing on its pharmacological mechanisms and emerging delivery strategies. METHODS: A comprehensive literature search was cond
PubMed: 41866921Natural Extracts in Skin Repair and Wound Healing: Phytochemical Mechanisms and Dermopharmaceutical Perspectives.
BACKGROUND: Skin repair and skin wound healing are tightly regulated biological processes that require coordinated control of inflammation, redox homeostasis, angiogenesis, and tissue remodelling. In this context, natural extracts are increasingly recognized as sources of chemically diverse phytochemicals capable of modulating defined molecular signalling pathways that govern cutaneous repair. METHODS: This review provides a mechanism-informed synthesis of current evidence by examining representative botanical sources, including Aloe vera, Centella asiatica, Curcuma longa, Calendula officinali
PubMed: 41900066Evaluation of liposome-encapsulated Centella asiatica ethanolic extract for enhanced in vitro and in vivo wound healing.
INTRODUCTION: Encapsulating herbal extracts with wound-healing properties in liposomes may enhance their stability and delivery performance. This study evaluated the biological efficacy of a liposome-encapsulated ethanolic extract of Centella asiatica (LEC) using in vitro and in vivo wound-healing models. METHODS: The ethanolic extract was incorporated into liposomes using the thin-film hydration method. Anti-inflammatory activity was assessed in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Cell viability and migration were evaluated in normal human dermal fibroblasts (NHDFs).
PubMed: 41657731Centella asiatica in dermatology: an overview.
Centella asiatica is a medicinal plant that was already used as a 'panacea' 3000 years ago. The active compounds include pentacyclic triterpenes, mainly asiaticoside, madecasosside, asiatic acid and madecassic acid. We have conducted an overview to summarize current knowledge on the results of scientific in vitro and in vivo experiments focused on the improvement of the healing process of small wounds, hypertrophic scars and burns by C. asiatica. In this paper, we discuss the data on constituents, recommended preparations and the potential side effects of C.
PubMed: 24399761A Systematic Review of the Effect of
BACKGROUND: Under metabolic stress conditions, there is a higher demand for nutrients which needs to be met. This is to reduce the risk of delay in wound healing which could lead to chronic wound. AIM: This is a systematic review of the effect of METHODS: PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed for the systematic review and four electronic databases were used. RESULTS: Four clinical trials met the inclusion criteria. The following distinct areas were identified under CONCLUSIONS:
PubMed: 35328954Contexto Científico
Los resultados demostraron que el asiaticósido estimula la producción de colágeno tipo I, lo que es fundamental para la cicatrización [PMID 41828505].
Seguridad y Precauciones
El uso de Centella asiatica requiere una supervisión cautelosa debido a su actividad biológica sobre diversos sistemas fisiológicos. En cuanto al embarazo y la lactancia, la Agencia Europea del Medicamento (EMA) establece una contraindicación estricta; debido a sus propiedades emenagogas (sustancias que estimulan el flujo sanguíneo en la región pélvica y uterina), su consumo puede inducir contracciones uterinas y, por ende, provocar un aborto espontáneo. Asimismo, estudios en modelos animales han demostrado una reducción de la fertilidad, por lo que se desaconseja su uso en mujeres que buscan la concepción. No existen datos suficientes que garanticen la seguridad de sus componentes, como el asiaticósido, durante la lactancia, por lo que se recomienda evitar su ingesta en este periodo. Respecto a la población pediátrica, su uso en niños menores de 12 años no está recomendado debido a la falta de estudios de seguridad clínica que determinen el impacto de sus triterpenos en sistemas endocrinos y neurológicos en desarrollo. En el ámbito de las interacciones farmacológicas, la Centella asiática puede potenciar peligrosamente los efectos de fármacos anticoagulantes como la warfarina, debido a posibles efectos sobre la agregación plaquetaria o la coagulación, aumentando el riesgo de hemorragias.
Otras plantas estudiadas para Cicatrización de heridas
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