Gaultheria reticulata para Estrés oxidativo
Gaultheria reticulata — 8 estudios científicos revisados
Moderate¿Sirve Gaultheria reticulata para estrés oxidativo?
Uso documentado en la medicina tradicional
Compuestos activos involucrados: Catequina, Flavonoides, Gaultherina, Lignanos, Quercetina, Rutina, Salicilato, Terpenoides, Terpenos, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Gaultheria reticulata y estrés oxidativo:
Anti-inflammatory, antioxidant and photoprotective activity of standardised Gaultheria procumbens L. leaf, stem, and fruit extracts in UVA-irradiated human dermal fibroblasts.
ETHNOPHARMACOLOGICAL RELEVANCE: Gaultheria procumbens L. is a polyphenolic-rich medicinal and food plant. Its leaves, stems, and fruits are traditional anti-inflammatory, antipyretic, antioxidant, and antimicrobial herbal medicines used to treat internal and external inflammation-related ailments, including rheumatic diseases, influenza, the common cold, fever, and skin and periodontal problems. Moreover, G. procumbens leaf extract is used for skin care as an anti-ageing and anti-wrinkle ingredient.
PubMed: 37742876Lignans and terpenoids from Gaultheria leucocarpa var. yunnanensis and their anti-inflammatory and antioxidant activities.
Six new compounds, including three lignans (1a, 1b, and 2), two abietane-type diterpenoids (3 and 4), and a triterpenoid (5), together with 13 known compounds (6a, 6b, and 7-17) were isolated from the aerial parts of Gaultheria leucocarpa var. yunnanensis. Their structures were elucidated by analysis of spectroscopic data involving NMR, IR, UV, and HRESIMS. The absolute configurations of lignans were confirmed by experimental and calculated ECD spectra. The anti-inflammatory and antioxidant activities of the isolates were evaluated.
PubMed: 36070814Isolation and characterization of secondary metabolites from Gaultheria tenuifolia berries.
Gaultheria berries (Ericaceae) are consumed as food or used in folk medicine throughout the world. In the present study, Gaultheria tenuifolia berries were studied to describe their polyphenol and iridoid composition, aroma volatiles, and cytoprotective effects. In total, 14 metabolites were isolated using a combination of countercurrent chromatography and Sephadex LH-20, namely, cyanidin-3-O-β-galactoside, cyanidin-3-O-β-arabinoside, 3-O-caffeoylquinic acid, 5-O-caffeoylshikimic acid, quercetin, quercetin-3-O-β-glucuronide, quercetin-3-O-β-rutinoside, quercetin-3-O-β-glucoside, quercetin-3-O-
PubMed: 32812218Gaultheria Ethnobotany and Bioactivity: Blueberry Relatives with Anti-inflammatory, Antioxidant, and Anticancer Constituents.
Gaultheria, a genus belonging to the Ericaceae family, is typically a shrub that produces berries, and closely resembles the blueberry genus Vaccinium. Gaultheria species are used worldwide especially as food and medicine in China. Certain Gaultheria species are biologically active, as antioxidants, anti-inflammatories, and cytotoxic agents. Through literature searches and field surveys, the results of ethnobotanical uses, especially in China, as well as in vitro and in vivo studies are reviewed critically. This review examines the chemistry and bioactivity of this under-studied plant genus, a
PubMed: 28971763Gaultheria leucocarpa inhibits Aβ fibrillization and enhances mitophagy-mediated degradation of pathogenic proteins.
Alzheimer's disease (AD) pathology involves amyloid-beta (Aβ) accumulation and neuronal toxicity, highlighting the need for therapeutic strategies that can both inhibit Aβ aggregation and promote pathogenic protein clearance. In this study, we identified Gaultheria leucocarpa as a medicinal plant with promising neuroprotective potential. Thioflavin T (ThT) fluorescence screening revealed that extracts from G. leucocarpa (GE), particularly the petroleum ether fraction of G. leucocarpa extract (GPF), effectively inhibited Aβ fibril formation in vitro.
PubMed: 40817000Contexto Científico
Aunque los resultados son prometedores y muestran mecanismos biológicos claros, todavía existe una brecha significativa: la falta de ensayos clínicos controlados en humanos a gran escala.
Seguridad y Precauciones
La seguridad en el uso de Gaultheria reticulata debe abordarse con extrema cautela debido a su composición química, específicamente por la presencia de derivados de salicilatos (como el salicilato de metilo y la gaultherina), los cuales son estructuralmente similares a la aspirina. (1) En el caso de embarazo y lactancia, el uso de esta planta está estrictamente contraindicado. Los salicilatos pueden atravesar la barrera placentaria y la barrera hematoencefálica, lo que representa un riesgo de toxicidad fetal. En el embarazo, la exposición a dosis elevadas de salicilatos se ha asociado con complicaciones como el cierre prematuro del ductus arterioso en el feto y riesgos de sangrado. Durante la lactancia, los compuestos pueden excretarse en la leche materna, lo que podría provocar síntomas de salicilismo en el lactante, como irritabilidad o alteraciones metabólicas. (2) Para niños menores de 12 años, el uso debe evitarse por completo.
Otras plantas estudiadas para Estrés oxidativo
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