Hypericum para Interacción farmacológica (Reducción de eficacia)
Hypericum fasciculatum — 10 estudios científicos revisados
Strong¿Sirve Hypericum para interacción farmacológica (reducción de eficacia)?
La inducción de las enzimas del citocromo P450 acelera la degradación de otros medicamentos en el hígado.
Compuestos activos involucrados:
Evidencia Científica
Los siguientes estudios han investigado la relación entre Hypericum y interacción farmacológica (reducción de eficacia):
Pharmacokinetic and pharmacodynamic herb-drug interactions-part I. Herbal medicines of the central nervous system.
Unlike conventional drug substances, herbal medicines are composed of a complex of biologically active compounds. Therefore, the potential occurrence of herb-drug interactions is even more probable than for drug-drug interactions. Interactions can occur on both the pharmacokinetic and pharmacodynamic level. Herbal medicines may affect the resulting efficacy of the concomitantly used (synthetic) drugs, mainly on the pharmacokinetic level, by changing their absorption, distribution, metabolism, and excretion. Studies on the pharmacodynamic interactions of herbal medicines and conventional drugs
PubMed: 38025741A review of effective herbal medicines in controlling menopausal symptoms.
BACKGROUND: Acute menopausal syndrome especially hot flashes, is one of the most common gynecological problems during menopause. Due to the side effects of hormone therapy, herbal and complementary medicines are always of immense interest to people in the treatment and management of the symptoms and complications of menopause. OBJECTIVE: The aim of this study was to investigate the mechanisms and effects of medicinal plants employed in the treatment of menopausal symptoms. METHODS: This review article was carried out by examining clinical trial studies between the period of 1994 and 2016. The
PubMed: 29403626Herbal medicines in the treatment of psychiatric disorders: 10-year updated review.
This paper provides a 10-year update of the 2007 systematic review of herbal medicines studied in a broad range of psychiatric disorders, including depression, anxiety, obsessive-compulsive, seasonal affective, bipolar, psychotic, phobic, somatoform, and attention-deficit hyperactivity disorders. Ovid Medline, PubMed, and the Cochrane Library were searched for herbal medicines with both pharmacological and clinical evidence of psychotropic activity. This updated review now covers clinical trial evidence for 24 herbal medicines in 11 psychiatric disorders. High-quality evidence was found to exi
PubMed: 29575228The Phytochemistry and Pharmacology of Hypericum.
Hypericum L. is a genus of the family Hypericaceae within the dicotyledones. The constituents of Hypericum species are valued for their important biological properties. Their use is in the treatment of depression and as antibacterial agents has been well documented in the primary literature and in ethnobotanical reports. The present contribution gives a comprehensive summary of the chemical constituents of members of the genus Hypericum and their biological effects.
PubMed: 33306173Phytomedicines in the Treatment of Migraine.
Migraine is a disabling neurovascular disorder with few targeted, tolerable and effective treatments. Phytomedicines, or plant-based medicinal formulations, hold great promise in the identification of novel therapeutic targets in migraine. Many patients also turn toward herbal and plant-based therapies for the treatment of their migraines as clinical and preclinical evidence of efficacy increases. Patients seek effective and tolerable treatments instead of or in addition to current conventional pharmacologic therapies. We review some phytomedicines potentially useful for migraine treatment-fev
PubMed: 30627973Seguridad y Precauciones
El uso de especies del género Hypericum, como Hypericum fasciculatum, requiere una vigilancia extrema debido a su perfil farmacológico complejo. En el caso de mujeres embarazadas o en periodo de lactancia, el uso de estas plantas está contraindicado debido a la falta de estudios clínicos que aseguren la ausencia de efectos teratogénicos (malformaciones fetales) o alteraciones en el desarrollo del lactante. Dado que los compuestos de Hypericum pueden atravesar la barrera placentaria y ser excretados en la leche materna, existe un riesgo potencial de toxicidad sistémica para el neonato. En niños menores de 12 años, la seguridad no ha sido establecida; su sistema nervioso en desarrollo es altamente sensible a los compuestos neuroactivos, lo que podría alterar procesos de maduración cerebral o causar efectos secundarios impredecibles. Uno de los riesgos más críticos es la interacción farmacológica. Las especies de Hypericum son potentes inductores de las enzimas del citocromo P450 (especialmente CYP3A4) y de la glicoproteína P.
Otras plantas estudiadas para Interacción farmacológica (Reducción de eficacia)
Perfil completo: Ver todos los usos y evidencia de Hypericum →