Hypericum para Ansiedad
Hypericum juniperinum — 4 estudios científicos revisados
Preclinical¿Sirve Hypericum para ansiedad?
Los extractos de Hypericum han mostrado actividad ansiolítica en modelos animales, posiblemente mediada por la interacción con receptores GABA.
Compuestos activos involucrados: Hipericina, Hiperforina, Floroglucinoles, Xantonas, Flavonoides, Diantronas
Evidencia Científica
Los siguientes estudios han investigado la relación entre Hypericum y ansiedad:
Herbal medicines in the treatment of psychiatric disorders: 10-year updated review.
This paper provides a 10-year update of the 2007 systematic review of herbal medicines studied in a broad range of psychiatric disorders, including depression, anxiety, obsessive-compulsive, seasonal affective, bipolar, psychotic, phobic, somatoform, and attention-deficit hyperactivity disorders. Ovid Medline, PubMed, and the Cochrane Library were searched for herbal medicines with both pharmacological and clinical evidence of psychotropic activity. This updated review now covers clinical trial evidence for 24 herbal medicines in 11 psychiatric disorders. High-quality evidence was found to exi
PubMed: 29575228Herbal medicines and perioperative care.
CONTEXT: Widespread use of herbal medications among the presurgical population may have a negative impact on perioperative patient care. OBJECTIVES: To review the literature on commonly used herbal medications in the context of the perioperative period and provide rational strategies for managing their preoperative use. DATA SOURCES: The MEDLINE and Cochrane Collaboration databases were searched for articles published between January 1966 and December 2000 using the search terms herbal medicine, phytotherapy, and alternative medicine and the names of the 16 most commonly used herbal medication
PubMed: 11448284Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research.
Depression is one of the most common diseases in the world, and it is also the most common mental disorder. Depressive disorders are a real threat not only to individuals, but also to the general population. This disease is a leading cause of disability and inability to work. Due to the numerous side effects of conventional drugs, attention is increasingly being paid to other solutions, including herbal medicines. Many plant species are known for their traditional uses in the treatment of anxiety, insomnia, and depression.
PubMed: 39598400St John's wort for depression.
BACKGROUND: Extracts of the plant Hypericum perforatum L. (popularly called St. John's wort) have been used in folk medicine for a long time for a range of indications including depressive disorders. OBJECTIVES: To investigate whether extracts of Hypericum are more effective than placebo and as effective as standard antidepressants in the treatment of depressive disorders in adults; and whether they have have less side effects than standard antidepressant drugs. SEARCH STRATEGY: Trials were searched in computerized general (Medline, Embase, Psychlit, Psychindex) and specialized databases (Coch
PubMed: 10796719Contexto Científico
While the study noted that other plants like Baccharis antioquensis showed higher absorption, the inclusion of Hypericum juniperinum in this high-altitude study highlights its natural evolutionary adaptation to oxidative stress and UV exposure.
Seguridad y Precauciones
La seguridad del uso de plantas del género Hypericum, específicamente en contextos donde se estudian sus propiedades químicas, requiere una vigilancia estricta debido a su compleja farmacología. En cuanto al embarazo y la lactancia, no existe evidencia suficiente en los estudios proporcionados para establecer un perfil de seguridad absoluto; sin embargo, debido a que los compuestos de Hypericum pueden tener efectos sobre el sistema nervioso central y actuar como inductores enzimáticos, se debe evitar su uso en mujeres gestantes y lactantes para prevenir la transferencia de metabolitos activos al feto o al lactante, así como para evitar posibles alteraciones en el desarrollo neurobiológico. Para niños menores de 12 años, el uso no está recomendado, ya que los efectos sobre la maduración del sistema enzimático hepático y el desarrollo psíquico en etapas tempranas son desconocidos y potencialmente riesgosos. Uno de los mayores peligros reside en las interacciones farmacológicas. Los componentes de Hypericum (como se observa en estudios de especies relacionadas como Hypericum perforatum) actúan como inductores de las enzimas del citocromo P450 (CYP) y de la glicoproteína P. Esto significa que la planta puede acelerar el metabolismo de otros fármacos, reduciendo su concentración en sangre a niveles sub-terapéuticos.
Otras plantas estudiadas para Ansiedad
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