Añil para Actividad antiinflamatoria
Indigofera suffruticosa — 10 estudios científicos revisados
Uso como febrífugo, validado en revisión, pmid 30631346¿Sirve Añil para actividad antiinflamatoria?
La investigación científica ha explorado el potencial de Añil (Indigofera suffruticosa) en relación con actividad antiinflamatoria. Se han identificado 10 estudios relevantes que examinan esta relación.
Compuestos activos involucrados: {'name': 'Indigotina', 'class': 'Pigmento indólico'}, {'name': 'Indirubina', 'class': 'Inhibidor de CDK'}, {'name': 'Isatina', 'class': 'Indol'}, {'name': 'Quercetina', 'class': 'Flavonol'}, {'name': 'Rotenona', 'class': 'Isoflavona'}, Alcaloides, Canavanina, Flavonoides, Glucógeno, Glucósidos, Indigotina, Indirubina, Insecticida, Isatina, Kaempferol, Quercetina, Rotenona, Saponinas, Taninos, ácido, ácido cafeico, ácido ferúlico, ácido gálico, Glucosinolatos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Añil y actividad antiinflamatoria:
Indigofera suffruticosa Mill. (Anil): Plant Profile, Phytochemistry, and Pharmacology Review.
Indigoferasuffruticosa Mill. (Fabaceae) is known as anil or anileira and also with other names, due to the production of a blue pigment, which is commonly used for yarn dyeing. It is distributed in some states of Brazil (Pernambuco, Paraíba, Mato Grosso, São Paulo, Bahia, Pará, and others) and is used in the popular medicine as a febrifuge, antispasmodic, diuretic, abortive, analgesic, purgative, or soothing agent against stomach and urinary problems, jaundice, and ulcers and also as an insecticide. In addition, I. suffruticosa can be used as animal feed.
PubMed: 30631346HEPATOPROTECTIVE EFFICACY OF METHANOLIC EXTRACT OF INDIGOFERA SUFFRUTICOSA (MILL) ON PARACETAMOL-INDUCED LIVER DAMAGE IN MICE.
BACKGROUND: Indigofera suffruticosa Mill (Fabaceae) is abundant in northeastern Brazil and popularly used in the treatment of infectious and inflammatory processes. Several biological properties, such as anti-inflammatory, anticancer, antitumor, hepatoprotective and low toxicity, are reported for this plant. OBJECTIVE: This study investigated hepatoprotective activity and the antioxidant effect of methanolic extract of I. suffruticosa leaves (MEIS) on Swiss albino mice submitted to experimental models of acetaminophen-induced liver injury. METHODS: MEIS (50 mg/kg; p.o.) was standardized accord
PubMed: 31721967Evaluation of the treatment of fever, pain and inflammation with Indigofera suffruticosa Miller Leaves Aqueous Extract.
ETHNOPHARMACOLOGICAL RELEVANCE: Indigofera suffruticosa has reports of its popular use for analgesy in several cultures. Besides that, all parts of this plant are used for some medicinal outcome. The leaves are used in teas, decoctions, juices and included in baths for treating fever and inflammatory processes. AIM OF THE STUDY: To evaluate the anti-inflammatory activity mechanisms of I. suffruticosa leave aqueous extract (IsAE).
PubMed: 34965459Suppressive effects of Indigofera suffruticosa Mill extracts on lipopolysaccharide-induced inflammatory responses in murine RAW 264.7 macrophages.
Indigofera suffruticosa Mill is used as an herbal medicine for the treatment of inflammation. The aim of this study is to assess the anti-inflammatory potency of I. suffruticosa and its likely molecular mechanisms of action in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Both water and ethanolic extracts of I. suffruticosa significantly decreased LPS-induced nitric oxide (NO) as well as the expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor-α, and pro-interleukin-1β.
PubMed: 23352929A review of traditional uses, phytochemistry and pharmacology of the genus Indigofera.
ETHNOPHARMACOLOGICAL RELEVANCE: Indigofera is the third-largest genus in the family of Fabaceae, with approximately 750 species. It is distributed across all tropical regions. Indigofera species are widely employed in traditional medicine all around the world, against many ailments. Thus, based on these medicinal properties, various investigations have been undertaken in order to appraise the pharmacological activities and the chemical composition of these species. A recent paper provides a summary of the phytochemistry and pharmacology of the genus Indigofera.
PubMed: 32004627Seguridad y Precauciones
El uso de Indigofera suffruticosa requiere precaución fundamentada en datos toxicológicos específicos de la especie. El riesgo más documentado es la toxicidad reproductiva: el extracto acuoso de hojas mostró efectos embriotóxicos en ratones durante la etapa de preimplantación, alterando el desarrollo embrionario temprano a concentraciones de 5-una dosis determinada/ml [PMID 15219632]. Por este motivo, el uso durante el embarazo está estrictamente contraindicado, especialmente durante el primer trimestre. Durante la lactancia, se desaconseja el uso interno por la posible presencia de compuestos indólicos bioactivos en la leche materna. El uso tradicional para expulsar la placenta posparto (documentado por Bussmann en Perú) refleja precisamente la actividad uterotónica de la planta, que debe ser aprovechada exclusivamente bajo supervisión de parteras o profesionales de salud experimentados. La presencia de rotenona en algunas preparaciones concentradas representa un riesgo adicional: este compuesto es neurotóxico en exposiciones crónicas y se ha asociado epidemiológicamente con aumento de riesgo de Parkinson.
Otras plantas estudiadas para Actividad antiinflamatoria
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