Loasa nitida para Inflamación
Loasa nitida — 4 estudios científicos revisados
Moderate¿Sirve Loasa nitida para inflamación?
Los flavonoides y polifenoles actúan modulando las vías inflamatorias mediante la inhibición de mediadores químicos.
Compuestos activos involucrados: Alcaloides, Fenoles, Flavonoides, Glucósido, Glucósidos, Monoterpeno, Polifenol, Polifenoles, Saponinas, Terpenos, Distribuido
Evidencia Científica
Los siguientes estudios han investigado la relación entre Loasa nitida y inflamación:
Anti-inflammatory activity of aqueous extracts of five Costa Rican medicinal plants in Sprague-Dawley rats.
The anti-inflammatory properties of Loasa speciosa and Loasa triphylla (Loasaceae), Urtica leptuphylla and Urera baccifera (Urticaceae), and Chaptalia nutans (Asteracene) were studied using the carregeenan induced rat paw edema model. Aqueous extracts of each plant were made according to the ethnobotanical use. The hippocratic assay was made with female rats; the dose used was 500 mg/kg i.p. and the control group received 0.5 ml of n.s.s.. All the animals treated showed hypothermia, and those treated with the extracts of Chaptalia nutans, Urera baccifera and Urtica leptuphylla showed an increa
PubMed: 11021310Anti-inflammatory and antinociceptive activities of Loasa speciosa in rats and mice.
In the range of doses of 250-500 mg/kg (given i.p.) the aqueous extract of Loasa speciosa leaves showed an inhibitory effect on leukocyte migration, and a reduction on the pleural exudate, as well as dose-dependent anti-inflammatory and peripheral antinociceptive activities.
PubMed: 12628394Edema induced by Bothrops asper (Squamata: Viperidae) snake venom and its inhibition by Costa Rican plant extracts.
We tested the capacity of leaf (Urera baccifera, Loasa speciosa, Urtica leptuphylla, Chaptalia nutans, and Satureja viminea) and root (Uncaria tomentosa) extracts to inhibit edema induced by Bothrops asper snake venom. Edema-forming activity was studied plethysmographically in the rat hind paw model. Groups of rats were injected intraperitoneally with various doses of each extract and, one hour later, venom was injected subcutaneously in the right hind paw. Edema was assessed at various time intervals. The edematogenic activity was inhibited in those animals that received an injection U.
PubMed: 18494294Iridoids from Loasa acerifolia.
In the course of preliminary chemotaxonomic studies on Loasaceae from South and Central America, 30 species from 6 genera were screened by chromatographic means. From the aerial parts of Loasa acerifolia Dombey, the novel trimeric and dimeric iridoid glucosides acerifolioside and tricoloroside methyl ester, consisting of loganin and secoxyloganin moieties, were isolated. The structures were primarily elucidated by NMR spectroscopy. Loganin, loganic acid, rutin, scopoletin and chlorogenic acid were identified by cochromatography with reference compounds.
PubMed: 9745765Seguridad y Precauciones
La seguridad del uso de Loasa nitida es un área de profunda incertidumbre científica debido a la carencia de ensayos clínicos controlados en humanos que avalen su consumo. En relación con el embarazo y la lactancia, su uso es altamente desaconsejable y debe evitarse estrictamente. Los alcaloides y los diversos glucósidos identificados en la planta tienen el potencial de cruzar las membranas biológicas, incluyendo la barrera placentaria y las glándulas mamarias, lo que plantea riesgos de toxicidad fetal o alteraciones en el desarrollo neurológico del lactante debido a la exposición a compuestos secundarios no regulados. Para la población pediátrica, específicamente niños menores de 12 años, el riesgo es crítico; la inmadurez de los sistemas de detoxificación hepática y la mayor permeabilidad de la barrera hematoencefálica en edades tempranas incrementan la susceptibilidad a los efectos neurotóxicos de los alcaloides y la toxicidad sistémica de las saponinas. Las interacciones medicamentosas representan un peligro significativo. La combinación con warfarina puede resultar peligrosa, ya que las saponinas y polifenoles pueden interferir con las vías de la coagulación sanguínea o la agregación plaquetaria, alterando la eficacia del anticoagulante y aumentando el riesgo de hemorragias.
Otras plantas estudiadas para Inflamación
Perfil completo: Ver todos los usos y evidencia de Loasa nitida →