Manayupa para Inflamación
Desmodium adscendens — 7 estudios científicos revisados
Preliminary¿Sirve Manayupa para inflamación?
Sus componentes como saponinas y flavonoides poseen propiedades antiinflamatorias que actúan sobre los procesos inflamatorios [PMID 21530632].
Compuestos activos involucrados: flavonoides, saponinas, triterpenoides, alcaloides, Quercetrina, Terpenoides, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Manayupa y inflamación:
An ethnomedicinal, phytochemical and pharmacological profile of Desmodium gangeticum (L.) DC. and Desmodium adscendens (Sw.) DC.
ETHNOPHARMACOLOGICAL RELEVANCE: Desmodium gangeticum (L.) DC. and Desmodium adscendens (Sw.) DC. are two important and well explored species of genus Desmodium (Fabaceae (alt. Leguminosae) subfamily: Faboideae). Desmodium gangeticum is used as a tonic, febrifuge, digestive, anticatarrhal, antiemitic, in inflammatory conditions of chest and in various other inflammatory conditions in the Ayurvedic System of Medicine while Desmodium adscendens is widely used for the treatment of asthma in Ghana, Africa.
PubMed: 21530632Activity-guided isolation, identification and quantification of biologically active isomeric compounds from folk medicinal plant Desmodium adscendens using high performance liquid chromatography with diode array detector, mass spectrometry and multidimentional nuclear magnetic resonance spectroscopy.
The antioxidant activity of the crude extract (60% ethanol) from the leaves of Desmodium adscendens (Sw.) DC. (Fabaceae) was observed in DPPH, xanthine/xanthine oxidase, lipid peroxydation and neutrophils burst tests. Further activity-guided fractionation on C18 column (water, 20% methanol, 50% methanol and 100% methanol) resulted in the separation of the fraction (50% methanol) with the highest antioxidant capacity. HPLC-DAD analysis of biologically active fraction revealed the presence of two pairs of flavonoid isomers as the dominant constituents. Those compounds were isolated and purified
PubMed: 25240729Desmodium styracifolium (Osb.) Merr. Extracts alleviate cholestatic liver disease by FXR pathway.
ETHNOPHARMACOLOGICAL RELEVANCE: Cholestatic liver disease (CLD) is a disease characterized by cholestasis. Farnesoid X receptor (FXR) is a nuclear receptor that maintains homeostasis in bile acid metabolism. Studies have shown that gut microbiota interfered with the FXR pathway. Modulation of FXR to inhibit cholestasis has become a key measure in the treatment of CLD. In traditional folk medicine, Desmodium styracifolium (Osb.) Merr.
PubMed: 39454708Desmodium caudatum (Thunb.) DC. extract attenuates hyperuricemia-induced renal fibrosis via modulating TGF-β1 pathway and uric acid transporters: Evidence from in vitro and in vivo studies.
ETHNOPHARMACOLOGICAL RELEVANCE: Desmodium caudatum (Thunb.) DC., a traditional Chinese medicinal herb, has been used to treat conditions such as rheumatic back pain, diarrhea, jaundice-related hepatitis, and abscesses; it also serves as an anthelmintic. The extract of Desmodium caudatum (Thunb.) DC. (DCE) is also known for its antioxidant and anti-inflammatory properties. However, its impact on kidney fibrosis remains unclear. AIM OF THE STUDY: This study investigated whether DCE can alleviate hyperuricemia-induced kidney fibrosis by modulating the transforming growth factor-β1 (TGF-β1) pathwa
PubMed: 40064319The genus Desmodium (Fabaceae)-traditional uses in Chinese medicine, phytochemistry and pharmacology.
ETHNOPHARMACOLOGICAL RELEVANCE: Plants of the genus Desmodium (Fabaceae), such as Desmodium styracifolium (Osbeck) Merr. and Desmodium gyrans (L. f.) DC., have a long history of medical use in Traditional Chinese Medicine to treat various ailments including rheumatism, pyrexia, dysentery, wounds, cough, malaria, hepatitis, hemoptysis, etc. In the theory of Traditional Chinese Medicine, most species have the effect of relieving internal heat or fever, neutralizing toxins, inhibiting pain, invigorating blood circulation, suppressing cough and alleviating dyspnea. MATERIALS AND METHODS: A bibliog
PubMed: 22004895Seguridad y Precauciones
El uso de la Manayupa (Desmodium adscendens) requiere una precaución extrema debido a la falta de estudios clínicos extensos en humanos que garanticen su seguridad absoluta. En relación con el embarazo y la lactancia, no existe evidencia científica que determine si los compuestos como los flavonoides o las saponinas presentes en la planta atraviesan la barrera placentaria o se excretan en la leche materna; por lo tanto, su uso está contraindicado en mujeres gestantes y lactantes para evitar riesgos potenciales al desarrollo fetal o neonatal. En niños menores de 12 años, el uso debe evitarse por completo, ya que sus sistemas metabólicos (hepático y renal) están en desarrollo y la toxicidad celular observada en concentraciones altas en estudios in vitro sugiere que podrían ser altamente vulnerables a efectos adversos. Respecto a las interacciones farmacológicas, la planta presenta riesgos significativos: la presencia de compuestos con actividad sobre el sistema nervioso central (efectos sedantes y de tipo serotonérgico observados en modelos animales [PMID 28710881]) podría potenciar peligrosamente fármacos psicotrópicos o ansiolíticos. Asimismo, debido a su potencial actividad sobre el metabolismo de ácidos grasos y la posible influencia en procesos enzimáticos, podría interferir con fármacos como la warfarina (alterando la coagulación) o la metformina. El uso de antihipertensivos debe ser vigilado debido a la capacidad de la planta para afectar la contractilidad del músculo liso [PMID 2120518].
Otras plantas estudiadas para Inflamación
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