Ajo sacha para Actividad antiinflamatoria
Mansoa alliacea — 8 estudios científicos revisados
Preliminary¿Sirve Ajo sacha para actividad antiinflamatoria?
La investigación científica ha explorado el potencial de Ajo sacha (Mansoa alliacea) en relación con actividad antiinflamatoria. Se han identificado 8 estudios relevantes que examinan esta relación.
Compuestos activos involucrados: {'name': 'Piranonaftoquinonas', 'class': 'Naftoquinonas'}, {'name': 'Ácido ursólico', 'class': 'Triterpenos'}, {'name': 'Ácido oleanólico', 'class': 'Triterpenos'}, {'name': 'Mansoínas A-F', 'class': 'Flavonoides oligoméricos'}, {'name': 'Compuestos organosulfurados', 'class': 'Tioésteres'}, Fenoles, Flavonoides, Naftoquinonas, Polifenoles, Terpenos, ácido oleanólico, ácido ursólico
Evidencia Científica
Los siguientes estudios han investigado la relación entre Ajo sacha y actividad antiinflamatoria:
Mansoins C-F, Oligomeric Flavonoid Glucosides Isolated from Mansoa hirsuta Fruits with Potential Anti-inflammatory Activity.
Continued investigation of the polyphenolic pool of the fruits of Mansoa hirsuta afforded four additional members of the new class of glucosylated oligomeric flavonoids comprising a flavanone core linked to 1,3-diarylpropane C6-C3-C6 units. The structures and absolute configurations of mansoins C-F (3-6) were established by analysis of NMR and electronic circular dichroism data. Mansoin C (3) was identified as a diglucosylated heterodimer, whereas mansoins D (4), E (5), and F (6) were identified as triglucosylated heterotrimers, isomeric with mansoin A (1). Mansoin F (6) inhibited TNF-α releas
PubMed: 27548746Toxicological and pharmacological effects of pentacyclic triterpenes rich fraction obtained from the leaves of Mansoa hirsuta.
Mansoa hirsuta is a medicinal plant native to the Brazilian semi-arid region. This approach aimed to investigate the in vitro and in vivo toxicity and anti-inflammatory and analgesic actions of the M. hirsuta fraction (MHF). In vitro cell viability was assessed in 3T3 cells. In vivo, the acute toxicity test, a single dose of the MHF was administered.
PubMed: 34872801TNF-α inhibition elicited by mansoins A and B, heterotrimeric flavonoids isolated from Mansoa hirsuta.
Mansoins A (1) and B (2) isolated from the fruits of Mansoa hirsuta represent new glucosylated heterotrimeric flavonoids with a flavanone core linked to two 1,3-diarylpropane C6-C3-C6 units. Their structures and absolute configurations were established by analysis of their NMR and electronic circular dichroism spectroscopic data. Compounds 1 and 2 inhibited TNF-α release by LPS-stimulated THP-1 cells with different potencies, with mansoin B (2) being active at lower concentrations than mansoin A (1) (IC50 values 20.0±1.4 and 48.1±1.8 μM, respectively). These results indicate potential anti-inf
PubMed: 24576254Mansoa alliacea extract presents antinociceptive effect in a chronic inflammatory pain model in mice through opioid mechanisms.
In some chronic disorders, as in arthritis, the inflammatory pain persists beyond the inflammation control becoming pathological. Its treatment shows limited efficacy and adverse effects which compromises patients' quality of life. Mansoa alliacea, known as 'cipo alho', is popularly used as analgesic and others species of this genus show anti-inflammatory actions. We investigated the anti-inflammatory and antinociceptive potential of M. alliacea extract in an inflammatory pain model which presents inflammatory characteristics similar to those caused by arthritis, through of the intraplantar in
PubMed: 30496767A liquid chromatography-atmospheric pressure photoionization tandem mass spectrometric (LC-APPI-MS/MS) method for the determination of triterpenoids in medicinal plant extracts.
An analytical method using liquid chromatography-atmospheric pressure photoionization tandem mass spectrometry with toluene as a dopant was developed for the determination of triterpenes in medicinal plant extracts. The 12 compounds determined have been shown to exhibit biological activity, such as gastroprotective, hepatoprotective, anti-inflammatory, antiviral and anti-tumor effects. The parameters of the atmospheric pressure photoionization interface were optimized to obtain the highest possible sensitivity for all of the compounds. The limits of detection and quantification ranged from 0.4
PubMed: 28239973Seguridad y Precauciones
La seguridad en el uso de Mansoa alliacea es un campo que requiere cautela, dado que la evidencia científica actual se concentra principalmente en modelos experimentales (animales) y no en ensayos clínicos extensos en humanos. En cuanto al embarazo y la lactancia, no existe evidencia científica suficiente que garantice la seguridad del consumo de extractos de Ajo sacha en mujeres gestantes o lactantes. Debido a que los compuestos bioactivos, como las piranonaftoquinonas y los triterpenos (ácido ursólico y oleanólico), pueden atravesar la barrera placentaria o excretarse en la leche materna, se recomienda evitar su uso para prevenir posibles efectos teratogénicos (malformaciones fetales) o alteraciones en el desarrollo del lactante. Para niños menores de 12 años, el uso debe ser estrictamente evitado. Los sistemas fisiológicos pediátricos, especialmente el metabolismo hepático y la función renal, están en desarrollo y son más susceptibles a la toxicidad de compuestos químicos complejos como los presentes en esta planta. En términos de interacciones farmacológicas, el Ajo sacha presenta riesgos significativos.
Otras plantas estudiadas para Actividad antiinflamatoria
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