Epená para Afecciones dermatológicas
Virola theiodora — 7 estudios científicos revisados
Moderate¿Sirve Epená para afecciones dermatológicas?
Uso documentado en la medicina tradicional y respaldado por investigación preliminar
Compuestos activos involucrados: Terpenos, Fenoles, Aceite esencial, Polifenoles, Esteroides, Saponinas, Alcaloides, Taninos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Epená y afecciones dermatológicas:
Development and Evaluation of
In regions adjacent to the Brazilian Atlantic Forest, Virola oleifera (VO) resin extract has been popularly used for decades as a skin and mucosal healing agent. However, this antioxidant-rich resin has not yet been investigated in wound healing, whose physiological process might also be aggravated by oxidative stress-related diseases (e.g., hypertension/diabetes). Our aim, therefore, was to investigate whether VO resin presents healing effects through an innovative cream for topical applications. For this, adult male Wistar rats were divided into four groups. Then, four 15 mm excisions were p
PubMed: 36139721Therapeutic and Diagnostic Landscape of Diabetic Neuropathy: A Systematic Review of Clinical Studies.
Diabetic neuropathy (DN) is one of the most prevalent complications of diabetes mellitus, affecting up to half of patients and contributing to disability, poor quality of life, and the risk of foot ulceration. Despite extensive research, its heterogeneous manifestations and complex pathophysiology continue to challenge timely diagnosis and effective treatment. This systematic review aimed to synthesize recent clinical evidence on diagnostic and therapeutic strategies for DN. A comprehensive search of PubMed, EMBASE, CENTRAL, and Web of Science identified 76 eligible clinical studies published
PubMed: 41788111Phytochemistry and Evaluation of the Anti-Inflammatory Activity of the Hydroethanolic Extract of
BACKGROUND: Previous studies of the hydroethanolic extract of METHODS: HEVe was obtained by maceration and phytochemically analyzed. Its systemic anti-inflammatory activity was assessed by its effect on lipopolysaccharide (LPS)-induced peritonitis in mice. HEVe gel (HEgVe) was employed to evaluate topical anti-inflammatory activity by measuring the ear edema resulting from croton-oil-induced dermatitis in mice. A cell viability assay was conducted to determine the non-cytotoxic concentrations of the HEVe. RAW 264.7 cells were stimulated by LPS to determinate cytokine and nitric oxide producti
PubMed: 39452085Evaluation of Virola oleifera activity in musculoskeletal pathologies: Inhibition of human multiple myeloma cells proliferation and combination therapy with dexamethasone or bortezomib.
ETHNOPHARMACOLOGICAL RELEVANCE: Virola oleifera (Schott) A.C. Smith, Myristicaceae, has been widely used in traditional medicine in Brazil to treat rheumatic pain, joint tumours, skin diseases, halitosis, bronchial asthma, haemorrhoids, and intestinal worms. Recently, research data showed the antioxidant properties in several oxidative stress-related models. However, there is no experimental evidence supporting its potential use in managing rheumatic diseases and bone malignancies. AIMS OF THE STUDY: To evaluate the therapeutic potential of the resin from Virola oleifera in joint and bone dise
PubMed: 33609728Gastroprotective activity of the resin from Virola oleifera.
CONTEXT: The resin from the trunk wood of Virola oleifera (Schott) A. C. Smith (Myristicaceae) is used in folk medicine to hasten wound repair and to treat pain and inflammatory conditions, and our previous report indicated the anti-oxidative properties in other oxidative stress model. OBJECTIVE: To investigate the protective effects of resin from V. oleifera in two experimental models of gastric ulcer oxidative-stress dependent.
PubMed: 27937036Contexto Científico
Study 1: Evaluation of Wound Healing (PMID 36139721). This study investigated the effectiveness of Virola oleifera (VO) resin in promoting wound contraction and reducing oxidative damage. Researchers created 15 mm excisions (wounds) on the rats' skin and applied the VO cream daily. The results showed that the VO-treated group achieved a 15% better wound contraction compared to the control group (p < 0 [PMID 9810278].05), along with significant reductions in lipid peroxidation (118%) and protein oxidation (110%) [PMID 27937036] [PMID 37714226]. In simple terms, the resin helped the skin close faster and protected the healing tissue from chemical damage caused by oxygen molecules.
Seguridad y Precauciones
La seguridad del uso de la resina de Epená (Virola theiodora) es un tema de extrema precaución debido a su complejidad química y su uso tradicional como enteógeno. No existen dosis terapéuticas estandarizadas para humanos, lo que eleva el riesgo de toxicidad accidental. En el caso de mujeres embarazadas o en periodo de lactancia, el uso de esta planta está estrictamente contraindicado. Debido a que los compuestos presentes (como flavonoides y lignanos) pueden atravesar la barrera placentaria o segregarse en la leche materna, existe un riesgo potencial de alteraciones en el desarrollo neurosensorial del feto o del lactante. La falta de estudios de seguridad en etapas de desarrollo humano hace que cualquier exposición sea un riesgo inaceptable. Para niños menores de 12 años, el uso es absolutamente contraindicado.
Otras plantas estudiadas para Afecciones dermatológicas
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