Epená para Estrés oxidativo
Virola theiodora — 9 estudios científicos revisados
Moderate¿Sirve Epená para estrés oxidativo?
Uso documentado en la medicina tradicional y respaldado por investigación preliminar
Compuestos activos involucrados: Terpenos, Fenoles, Aceite esencial, Polifenoles, Esteroides, Saponinas, Alcaloides, Taninos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Epená y estrés oxidativo:
Development and Evaluation of
In regions adjacent to the Brazilian Atlantic Forest, Virola oleifera (VO) resin extract has been popularly used for decades as a skin and mucosal healing agent. However, this antioxidant-rich resin has not yet been investigated in wound healing, whose physiological process might also be aggravated by oxidative stress-related diseases (e.g., hypertension/diabetes). Our aim, therefore, was to investigate whether VO resin presents healing effects through an innovative cream for topical applications. For this, adult male Wistar rats were divided into four groups. Then, four 15 mm excisions were p
PubMed: 36139721Evaluation of Virola oleifera activity in musculoskeletal pathologies: Inhibition of human multiple myeloma cells proliferation and combination therapy with dexamethasone or bortezomib.
ETHNOPHARMACOLOGICAL RELEVANCE: Virola oleifera (Schott) A.C. Smith, Myristicaceae, has been widely used in traditional medicine in Brazil to treat rheumatic pain, joint tumours, skin diseases, halitosis, bronchial asthma, haemorrhoids, and intestinal worms. Recently, research data showed the antioxidant properties in several oxidative stress-related models. However, there is no experimental evidence supporting its potential use in managing rheumatic diseases and bone malignancies. AIMS OF THE STUDY: To evaluate the therapeutic potential of the resin from Virola oleifera in joint and bone dise
PubMed: 33609728Chronic administration of antioxidant resin from Virola oleifera attenuates atherogenesis in LDLr
ETHNOPHARMACOLOGICAL RELEVANCE: Virola oleifera (Schott) A. C. Smith, Myristicaceae has been largely used in traditional folk medicine in Brazil as an anti-inflammatory agent and our previous data indicated the antioxidant properties in other oxidative stress-related models. However, its effects on atherosclerosis (AT) are not yet investigated. AIMS OF THE STUDY: To evaluate the influence of resin from Virola oleifera (RV) on progression of AT in LDLr MATERIALS AND METHODS: LDLr RESULTS: We showed that the chronic treatment of RV at both doses reduced vascular lipid accumulation (~50%, p<0.05)
PubMed: 28502908Virola oleifera-capped gold nanoparticles showing radical-scavenging activity and low cytotoxicity.
The development of effective nanoparticle therapeutics has been hindered by their surface characteristics, such as hydrophobicity and charge. Therefore, the success of biomedical applications with nanoparticles is governed by the control of these characteristics. In this article, we report an efficient green capping method for gold nanoparticles (AuNPs) by a reduction with sodium citrate and capping with Virola oleifera (Vo), which is a green exudate rich in polyphenols and flavonoids. The Vo-capped AuNPs were characterized by UV, DLS, FTIR, Raman, TEM, DPPH, FRAP and their cytotoxicity was ev
PubMed: 30033320Resin from Virola oleifera Protects Against Radiocontrast-Induced Nephropathy in Mice.
Contrast-induced nephropathy (CIN) is an iatrogenic medical event for which there is not yet a successful therapy. Increasing evidence in rodents has suggested that this disease is associated with renal tubular and vascular injury that is triggered directly by oxidative stress. In the present study, we evaluated whether the antioxidant resin from Virola oleifera (RV) could attenuate renal damage in an experimental mouse model of CIN. Adult male Swiss mice were divided into six groups and pre-treated orally with RV (10, 100 and 300 mg/kg), N-acetylcysteine (200 mg/kg) or vehicle for 5 days befo
PubMed: 26674346Contexto Científico
These nanoparticles showed high antioxidant activity and low toxicity to the cells. This means the plant's chemistry can be used to create advanced medical tools, like tiny particles for drug delivery, that are safe and effective at fighting oxidative stress. This study investigated the potential of Virola oleifera resin in managing musculoskeletal pathologies, specifically multiple myeloma (a type of blood cancer), osteosarcoma (bone cancer), and chondrosarcoma. The results showed that the resin improved renal function, lowered mortality, and reduced oxidative stress and cell death (apoptosis) in the kidney tissues. Summary of Evidence: The current state of evidence for Virola species is robust in laboratory (in vitro) and animal (in vivo) models, showing significant potential in antioxidant, anti-cancer, and organ-protective activities.
Seguridad y Precauciones
La seguridad del uso de la resina de Epená (Virola theiodora) es un tema de extrema precaución debido a su complejidad química y su uso tradicional como enteógeno. No existen dosis terapéuticas estandarizadas para humanos, lo que eleva el riesgo de toxicidad accidental. En el caso de mujeres embarazadas o en periodo de lactancia, el uso de esta planta está estrictamente contraindicado. Debido a que los compuestos presentes (como flavonoides y lignanos) pueden atravesar la barrera placentaria o segregarse en la leche materna, existe un riesgo potencial de alteraciones en el desarrollo neurosensorial del feto o del lactante. La falta de estudios de seguridad en etapas de desarrollo humano hace que cualquier exposición sea un riesgo inaceptable. Para niños menores de 12 años, el uso es absolutamente contraindicado.
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