Zanthoxylum americanum para Actividad antifúngica
Zanthoxylum americanum — 5 estudios científicos revisados
Moderate¿Sirve Zanthoxylum americanum para actividad antifúngica?
Los extractos de la hoja y el fruto poseen una actividad de amplio espectro contra diversos hongos como Candida albicans y Aspergillus fumigatus, debido a su alto contenido de furanocumarinas (PMID 15957372).
Compuestos activos involucrados: Cumarinas, Imperatorina, Lignanos, Piranocumarina
Evidencia Científica
Los siguientes estudios han investigado la relación entre Zanthoxylum americanum y actividad antifúngica:
Antifungal constituents of northern prickly ash, Zanthoxylum americanum mill.
Leaf, fruit, stem, bark and root of Zanthoxylum americanum were investigated for antifungal activity with 11 strains of fungi representing diverse opportunistic and systemic pathogens, including Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. All extracts demonstrated a broad spectrum of antifungal activity and inhibited at least eight fungal species in a disk diffusion assay (600 microg/disk). Antifungal activity was light-dependent, with fruit and leaf extracts most active in general. The presence of light-mediated compounds, such as psoralen, 8-methoxypsoralen and imper
PubMed: 15957372Inhibition of DNA polymerization and antifungal specificity of furanocoumarins present in traditional medicines.
Antifungal activity is positively correlated to furanocoumarin content in extracts of the traditional phytomedicine northern prickly ash (Zanthoxylum americanum Mill. [Rutaceae]). The specificity of these furanocoumarins in inhibiting replication of DNA was investigated with reference to significant base composition differences between fungal and mammalian mitochondrial DNA. We developed a polymerase chain reaction-based assay to investigate whether (1) furanocoumarins inhibit DNA polymerization and (2) distinct furanocoumarins specifically inhibit DNA replication depending on base composition
PubMed: 15291300Antispasmodic Potential of Medicinal Plants: A Comprehensive Review.
Numerous medicinal plants have been utilized for the treatment of different types of diseases and disorders including gastrointestinal (GI) diseases. GI diseases are the most common complaints that normally affects the largest proportion of children and adolescents with overlapping clinical manifestation in diagnosis and medical needs. Drugs with antispasmodic effects are normally applied for the symptomatic treatment of contraction and cramping of smooth muscles in gastrointestinal diseases as well as in other critical clinical situations. In alternative system of medicines, the antispasmodic
PubMed: 34804367Ethnobotanical survey and toxicity evaluation of medicinal plants used for fungal remedy in the Southern Highlands of Tanzania.
BACKGROUND/AIM: Some of the antifungal drugs used in the current treatments regime are responding to antimicrobial resistance. In rural areas of Southern Tanzania, indigenous people use antifungal drugs alone or together with medicinal plants to curb the effects of antibiotic resistance. This study documented ethnobotanical information of medicinal plants used for managing fungal infections in the Southern Highlands of Tanzania and further assess their safety. MATERIALS AND METHODS: Ethnobotanical survey was conducted in Makete and Mufindi districts between July 2014 and December 2015 using se
PubMed: 28163965PRISMA Based Systematic Review: Pharmacognostic Study of Zanthoxylum armatum DC.
INTRODUCTION: Herb, Zanthoxylum armatum DC., commonly called Indian prickly ash, and Nepal pepper (family Rutaceae), is widely utilized in the traditional medicinal system. OBJECTIVE: The current review provides requisite data for collecting descriptive information on the organoleptic, microscopical, ethnobotanical use, and phytochemicals and pharmacological properties of Z. armatum; therefore, it may help in forming a bridge between research gaps and the upcoming future findings for most of the researches. MATERIALS AND METHODS: The systematic literature survey was conducted using the PRISMA
PubMed: 33390134Seguridad y Precauciones
La seguridad en el uso de Zanthoxylum americanum es un área que requiere extrema cautela debido a su compleja composición química, la cual incluye furanocumarinas como la psoralen y la 8-metoxipsoralen, así como lignanos y diversos alcaloides. En lo que respecta al embarazo y la lactancia, no existen estudios clínicos que garanticen la inocuidad de esta especie en mujeres gestantes o lactantes; por lo tanto, su uso debe evitarse estrictamente en estas etapas para prevenir posibles riesgos de toxicidad fetal o transferencia de compuestos bioactivos a través de la leche materna. Para niños menores de 12 años, la administración de extractos de Zanthoxylum americanum no está recomendada, ya que la sensibilidad de los sistemas enzimáticos y metabólicos en edades tempranas podría reaccionar de forma adversa a los compuestos citotóxicos identificados en el género, como la dipetalin o la xanthoxyletin, que han mostrado actividad inhibidora en células leucémicas (PMID 11507740). Respecto a las interacciones farmacológicas, se debe tener especial cuidado con medicamentos que afecten el metabolismo hepático o que tengan efectos sobre el ADN, dado que los furanocumarinos presentes en la planta pueden inhibir la polimerización del ADN (PMID 15291300). No se ha establecido una dosis máxima segura para el consumo humano en la literatura científica disponible, lo que imposibilita determinar un límite de toxicidad clínica. Los efectos secundarios potenciales incluyen reacciones cutáneas de fototoxicidad debido a la presencia de furanocumarinas, que pueden sensibilizar la piel a la luz ultravioleta, y posibles efectos citotóxicos sistémicos.
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Otras plantas estudiadas para Actividad antifúngica
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