Gymnema sylvestre para Diabetes
Gymnema sylvestre — 19 estudios científicos revisados
In_vivo¿Sirve Gymnema sylvestre para diabetes?
Este estudio sugiere que la planta no solo actúa bloqueando la absorción, sino que podría modular directamente las señales de la insulina y otros marcadores genéticos relacionados con la diabetes,...
Compuestos activos involucrados: ácido gimnémico, gimnemagenina, gurmarina, Flavonoides, Gymnemasaponina, Saponina, Saponinas, Terpenoides, ácido
Evidencia Científica
Los siguientes estudios han investigado la relación entre Gymnema sylvestre y diabetes:
Deciphering diabetes-related genetic markers using in silico methods: insights into Gymnema sylvestre's therapeutic role for diabetes mellitus.
UNLABELLED: Gymnema sylvestre, a medicinal plant renowned for its anti-diabetic properties, has long been used in traditional medicine. Its active compound, gymnemic acid, is known to regulate glucose metabolism and inhibit sugar absorption, making it a promising compound for Diabetes mellitus management. This study investigates the molecular interactions between gymnemic acid and five proteins critical to glucose regulation, circadian rhythm, immune response, and insulin signaling. Gene enrichment analysis was performed using the STRING database to examine the functional connections between t
PubMed: 41858338Exploration and validation of anti-diabetic potential of terpenoid phytocompounds from Indian traditional medicinal plant Gymnema sylvestre.
UNLABELLED: Diabetes is a long-lasting condition of glucose metabolism caused by abnormalities in insulin secretion and effectiveness. Type 2 diabetes with persistent hyperglycemia, managed with various hypoglycemic medications, has severe adverse effects and can harm vital organs. Anti-diabetic medication from Indian traditional medicinal plants has shown no such side effects. The current study aimed to explore and assess the antidiabetic potential of terpenoid phytocompounds from two types of Gymnema sylvestre extracts. The current study utilized various analytical methods to validate anti-d
PubMed: 41767849An in vitro, in vivo and in silico assessment of fat absorption inhibition by a gymnemic acid rich extract of Gymnema sylvestre leaves.
ETHNOPHARMACOLOGICAL RELEVANCE: Hyperlipidemia is a metabolic disturbance linked to the metabolic syndrome, obesity, and diabetes. Gymnema sylvestre is a plant used in Ayurvedic folk medicine to control hyperglycemia and hyperlipidemia. These effects have received support by a fair number of investigations. AIM OF THE STUDY: The objective of this study was to elucidate the mechanisms underlying the anti-hyperlipidemic effects of a commercial extract derived from Gymnema sylvestre leaves, standardized to 75 % gymnemic acids ("Gymnema sylvestre 75"). MATERIALS AND METHODS: In vivo, in vitro and
PubMed: 40550293Evaluation and screening of polyherbal formulation for diabetes management: toxicity assessment on Albino Wistar rats.
Diabetes remains a global health concern, leading to interest in herbal formulations for safer, effective management. The study screens the polyherbal formulations (PHF 1-5) using Costus pictus, Gymnema sylvestre, and Momordica charantia to identify the most effective synergistic ratio and evaluate the stability and safety as per the Central Council for Research in Ayurvedic Sciences (CCRAS) and Organisation for Economic Co-operation and Development (OECD) guidelines (423 and 407). PHF-3 exhibited maximum synergistic potential by in vitro antioxidant and antidiabetic activities (α-amylase inhi
PubMed: 40383985The effect of Gymnema sylvestre supplementation on glycemic control in type 2 diabetes patients: A systematic review and meta-analysis.
This systematic review and meta-analysis aims to find the effect of Gymnema sylvestre (GS) supplementation on glycemic control in type-2 diabetes mellitus (T2DM). PubMed, Cochrane library, Google Scholar, and Science Direct were searched from inception to June 2020 to identify the studies that reported GS supplementation on glycemic parameters. Standardized mean difference (SMD) was calculated by comparing the post-intervention data with baseline data. SMDs with 95% confidence intervals (CIs) were pooled using a random-effects model. Our meta-analysis consisting of 10 studies with a total of 4
PubMed: 34467577Seguridad y Precauciones
El uso de Gymnema sylvestre debe abordarse con extrema precaución debido a su potente actividad metabólica. En relación con el embarazo y la lactancia, no existe evidencia científica suficiente que garantice la seguridad en humanos; por lo tanto, su uso está contraindicado en mujeres gestantes y lactantes, ya que los efectos de los ácidos gimnémicos sobre el desarrollo fetal y la transferencia de compuestos bioactivos a través de la leche materna no han sido estudiados. En el caso de niños menores de 12 años, se desaconseja su administración debido a que sus sistemas endocrinos y metabólicos están en desarrollo, y la interferencia con la regulación de la glucosa y el crecimiento podría tener consecuencias impredecibles. Respecto a las interacciones farmacológicas, la Gymnema sylvestre presenta riesgos significativos de interacción con fármacos hipoglucemiantes como la metformina, ya que la planta potencia la reducción de la glucosa en sangre, lo que podría derivar en episodios de hipoglucemia severa por un efecto sinérgico no controlado. Asimismo, puede interactuar con la warfarina y otros anticoagulantes, alterando potencialmente la respuesta hematológica, aunque la evidencia es limitada. También debe evitarse su combinación con antihipertensivos, dado que la modulación metabólica de la planta podría influir en la presión arterial de forma indirecta.
Otras plantas estudiadas para Diabetes
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