Hypericum para Interacción farmacocinética (reducción de eficacia de fármacos)
Hypericum aegypticum — 4 estudios científicos revisados
Strong¿Sirve Hypericum para interacción farmacocinética (reducción de eficacia de fármacos)?
Inducción de enzimas hepáticas (CYP450) que aceleran la eliminación de medicamentos de la sangre.
Compuestos activos involucrados: Flavonoides, Quercetina, Rutina, Terpenos, Ácido cafeico, Ácido clorogénico, α-pineno
Evidencia Científica
Los siguientes estudios han investigado la relación entre Hypericum y interacción farmacocinética (reducción de eficacia de fármacos):
Herbal medicines in the treatment of psychiatric disorders: 10-year updated review.
This paper provides a 10-year update of the 2007 systematic review of herbal medicines studied in a broad range of psychiatric disorders, including depression, anxiety, obsessive-compulsive, seasonal affective, bipolar, psychotic, phobic, somatoform, and attention-deficit hyperactivity disorders. Ovid Medline, PubMed, and the Cochrane Library were searched for herbal medicines with both pharmacological and clinical evidence of psychotropic activity. This updated review now covers clinical trial evidence for 24 herbal medicines in 11 psychiatric disorders. High-quality evidence was found to exi
PubMed: 29575228Adverse effects of herbal medicines: an overview of systematic reviews.
This overview of systematic reviews (SRs) aims to evaluate critically the evidence regarding the adverse effects of herbal medicines (HMs). Five electronic databases were searched to identify all relevant SRs, with 50 SRs of 50 different HMs meeting our inclusion criteria. Most had only minor weaknesses in methods. Serious adverse effects were noted only for four HMs: Herbae pulvis standardisatus, Larrea tridentate, Piper methysticum and Cassia senna. The most severe adverse effects were liver or kidney damage, colon perforation, carcinoma, coma and death.
PubMed: 23472485Ethnobotanical and ethnomedicinal research into medicinal plants in the Mt Stara Planina region (south-eastern Serbia, Western Balkans).
BACKGROUND: Ethnobotanical research in Southeast Europe-one of the most important European hotspots for biocultural diversity-is significant for the acquisition of Traditional Ecological Knowledge related to plants as well as for encouraging the development of local environments. The current ethnobotanical research was conducted in the region of Mt Stara Planina (south-eastern Serbia), which is characterised by rich phytodiversity with a large number of endemic and relict plant species. The aim of the study was to document the diversity of uses of medicinal plants and of traditional knowledge
PubMed: 38200599Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research.
Depression is one of the most common diseases in the world, and it is also the most common mental disorder. Depressive disorders are a real threat not only to individuals, but also to the general population. This disease is a leading cause of disability and inability to work. Due to the numerous side effects of conventional drugs, attention is increasingly being paid to other solutions, including herbal medicines. Many plant species are known for their traditional uses in the treatment of anxiety, insomnia, and depression.
PubMed: 39598400Seguridad y Precauciones
El uso de Hypericum aegypticum requiere una vigilancia extrema debido a su perfil fitoquímico complejo. En el caso de embarazo y lactancia, no existe evidencia científica suficiente que garantice la seguridad del desarrollo fetal o neonatal; por lo tanto, su uso está estrictamente contraindicado. Los compuestos como los flavonoides y terpenos pueden atravesar la barrera placentaria o excretarse en la leche materna, con riesgos potenciales de toxicidad sistémica en el infante o alteraciones en el desarrollo. Para niños menores de 12 años, la seguridad es desconocida y se desaconseja su administración, ya que los sistemas enzimáticos hepáticos infantiles son inmaduros y pueden reaccar de forma impredecible ante extractos concentrados. En cuanto a las interacciones farmacológicas, el género Hypericum es conocido por su capacidad de inducir enzimas del citocromo P450 (específicamente CYP3A4) y la glicoproteína P. Esto significa que la planta puede acelerar el metabolismo de otros medicamentos, reduciendo su concentración en sangre a niveles sub-terapéuticos.
Otras plantas estudiadas para Interacción farmacocinética (reducción de eficacia de fármacos)
Perfil completo: Ver todos los usos y evidencia de Hypericum →