Hypericum para Interacción farmacocinética (reducción de eficacia de fármacos)
Hypericum aethiopicum — 6 estudios científicos revisados
Moderate¿Sirve Hypericum para interacción farmacocinética (reducción de eficacia de fármacos)?
La inducción de enzimas metabólicas (como el citocromo P450) puede acelerar la degradación de medicamentos en el hígado, bajando su concentración en sangre.
Compuestos activos involucrados: {'name': 'Hipericina', 'class': 'Naftodiantrona'}, {'name': 'Quercetina', 'class': 'Flavonoide'}, {'name': 'Ácido clorogénico', 'class': 'Ácido fenólico'}
Evidencia Científica
Los siguientes estudios han investigado la relación entre Hypericum y interacción farmacocinética (reducción de eficacia de fármacos):
An antimicrobial investigation of plants used traditionally in southern Africa to treat sexually transmitted infections.
AIM OF THE STUDY: Eighteen plants were assessed for antimicrobial activity against pathogens associated with prevalent urogenital/sexually transmitted infections. Plant selection was based on information obtained from the ethnobotanical literature. MATERIALS AND METHODS: Dried plant material was submerged in a 1:1 mixture of methanol and dichloromethane for 24 h. Aqueous extracts were prepared by submerging dried plant material in sterile distilled water for 24 h followed by lyophilization. Essential oils were distilled from the two aromatic plant species (Tarchonanthus camphoratus and Croton
PubMed: 20561928Antimicrobial Activity, Phenolic Content, and Cytotoxicity of Medicinal Plant Extracts Used for Treating Dermatological Diseases and Wound Healing in KwaZulu-Natal, South Africa.
Medicinal plants used for wound healing and skin diseases are the key to unlocking the doors to combating problematic skin diseases as resistance of pathogens to pharmaceuticals and allopathic management continues to increase. The study aimed at investigating the antimicrobial efficacies, phenolic content, and cytotoxicity effects of 11 medicinal plant extracts commonly used for treating skin conditions and wound healing in traditional medicine within KwaZulu-Natal. Eleven plant species were separated into different plant parts (bulbs, roots, leaves) and extracted with different solvents. The
PubMed: 27746731Herbal medicines in the treatment of psychiatric disorders: 10-year updated review.
This paper provides a 10-year update of the 2007 systematic review of herbal medicines studied in a broad range of psychiatric disorders, including depression, anxiety, obsessive-compulsive, seasonal affective, bipolar, psychotic, phobic, somatoform, and attention-deficit hyperactivity disorders. Ovid Medline, PubMed, and the Cochrane Library were searched for herbal medicines with both pharmacological and clinical evidence of psychotropic activity. This updated review now covers clinical trial evidence for 24 herbal medicines in 11 psychiatric disorders. High-quality evidence was found to exi
PubMed: 29575228Adverse effects of herbal medicines: an overview of systematic reviews.
This overview of systematic reviews (SRs) aims to evaluate critically the evidence regarding the adverse effects of herbal medicines (HMs). Five electronic databases were searched to identify all relevant SRs, with 50 SRs of 50 different HMs meeting our inclusion criteria. Most had only minor weaknesses in methods. Serious adverse effects were noted only for four HMs: Herbae pulvis standardisatus, Larrea tridentate, Piper methysticum and Cassia senna. The most severe adverse effects were liver or kidney damage, colon perforation, carcinoma, coma and death.
PubMed: 23472485Ethnobotanical and ethnomedicinal research into medicinal plants in the Mt Stara Planina region (south-eastern Serbia, Western Balkans).
BACKGROUND: Ethnobotanical research in Southeast Europe-one of the most important European hotspots for biocultural diversity-is significant for the acquisition of Traditional Ecological Knowledge related to plants as well as for encouraging the development of local environments. The current ethnobotanical research was conducted in the region of Mt Stara Planina (south-eastern Serbia), which is characterised by rich phytodiversity with a large number of endemic and relict plant species. The aim of the study was to document the diversity of uses of medicinal plants and of traditional knowledge
PubMed: 38200599Seguridad y Precauciones
El uso de Hypericum aethiopicum requiere una vigilancia extrema debido a su potencial de interacciones bioquímicas complejas. En el caso de mujeres embarazadas o en periodo de lactancia, el uso de esta planta no se recomienda bajo ninguna circunstancia debido a la falta de estudios de seguridad clínica que garanticen que sus compuestos no atraviesen la barrera placentaria o se secreten en la leche materna. La exposición fetal o neonatal a compuestos bioactivos de plantas con actividad enzimática puede alterar el desarrollo fisiológico del infante. Asimismo, el uso en niños menores de 12 años debe evitarse estrictamente, ya que los sistemas metabólicos y de aclaramiento renal/hepático en etapas de crecimiento son altamente sensibles a la inducción enzimática y a la toxicidad sistémica, lo que podría interferir con procesos hormonales críticos. Respecto a las interacciones farmacológicas, aunque los datos específicos de H. aethiopicum son limitados, se debe extrapolar la precaución observada en especies del género Hypericum.
Otras plantas estudiadas para Interacción farmacocinética (reducción de eficacia de fármacos)
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