Hypericum para Interacción farmacocinética (reducción de eficacia de fármacos)
Hypericum elodes — 5 estudios científicos revisados
Strong¿Sirve Hypericum para interacción farmacocinética (reducción de eficacia de fármacos)?
Inducción de enzimas hepáticas (CYP450) que aceleran la eliminación de medicamentos de la sangre.
Compuestos activos involucrados:
Evidencia Científica
Los siguientes estudios han investigado la relación entre Hypericum y interacción farmacocinética (reducción de eficacia de fármacos):
Detection of hypericins in the "red glands" of Hypericum elodes by ESI-MS/MS.
The biologically active naphthodianthrones hypericin and pseudohypericin were detected by electrospray ionization mass spectrometry (ESI-MS/MS) in microsamples from the sepals of Hypericum elodes (Hypericaceae) containing the so-called "red glands", i.e. stipitate glands with red-coloured heads. The occurrence of hypericins in the red glands of H. elodes supports the taxonomic position of the section Elodes within the genus Hypericum and provides evidence that the ability of carrying out the biosynthetic pathway leading to the naphthodianthrone compounds, rather than the absolute amounts produ
PubMed: 14759533Herbal medicines in the treatment of psychiatric disorders: 10-year updated review.
This paper provides a 10-year update of the 2007 systematic review of herbal medicines studied in a broad range of psychiatric disorders, including depression, anxiety, obsessive-compulsive, seasonal affective, bipolar, psychotic, phobic, somatoform, and attention-deficit hyperactivity disorders. Ovid Medline, PubMed, and the Cochrane Library were searched for herbal medicines with both pharmacological and clinical evidence of psychotropic activity. This updated review now covers clinical trial evidence for 24 herbal medicines in 11 psychiatric disorders. High-quality evidence was found to exi
PubMed: 29575228Adverse effects of herbal medicines: an overview of systematic reviews.
This overview of systematic reviews (SRs) aims to evaluate critically the evidence regarding the adverse effects of herbal medicines (HMs). Five electronic databases were searched to identify all relevant SRs, with 50 SRs of 50 different HMs meeting our inclusion criteria. Most had only minor weaknesses in methods. Serious adverse effects were noted only for four HMs: Herbae pulvis standardisatus, Larrea tridentate, Piper methysticum and Cassia senna. The most severe adverse effects were liver or kidney damage, colon perforation, carcinoma, coma and death.
PubMed: 23472485Ethnobotanical and ethnomedicinal research into medicinal plants in the Mt Stara Planina region (south-eastern Serbia, Western Balkans).
BACKGROUND: Ethnobotanical research in Southeast Europe-one of the most important European hotspots for biocultural diversity-is significant for the acquisition of Traditional Ecological Knowledge related to plants as well as for encouraging the development of local environments. The current ethnobotanical research was conducted in the region of Mt Stara Planina (south-eastern Serbia), which is characterised by rich phytodiversity with a large number of endemic and relict plant species. The aim of the study was to document the diversity of uses of medicinal plants and of traditional knowledge
PubMed: 38200599Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research.
Depression is one of the most common diseases in the world, and it is also the most common mental disorder. Depressive disorders are a real threat not only to individuals, but also to the general population. This disease is a leading cause of disability and inability to work. Due to the numerous side effects of conventional drugs, attention is increasingly being paid to other solutions, including herbal medicines. Many plant species are known for their traditional uses in the treatment of anxiety, insomnia, and depression.
PubMed: 39598400Seguridad y Precauciones
El uso de Hypericum elodes requiere una vigilancia extrema debido a su complejo perfil farmacológico. En el contexto de embarazo y lactancia, no se recomienda su consumo. Aunque la evidencia específica para H. elodes es limitada, los compuestos de este género, como las naftodiantronas (hipericina) y derivados de floroglucinol (hiperforina) detectados en sus glándulas rojas [PMID 14759533], pueden atravesar la barrera placentaria o pasar a la leche materna. No existen estudios que garanticen la seguridad fetal, y el riesgo de toxicidad sistémica en el neonato es una preocupación clínica válida. Para niños menores de 12 años, el uso está estrictamente contraindicado debido a la inmadurez de sus sistemas enzimáticos hepáticos y la falta de datos sobre el desarrollo neurológico bajo la influencia de estos compuestos.
Otras plantas estudiadas para Interacción farmacocinética (reducción de eficacia de fármacos)
Perfil completo: Ver todos los usos y evidencia de Hypericum →