Lampaya para Actividad antirreumática
Lampaya medicinalis — 7 estudios científicos revisados
Efecto antiinflamatorio confirmado in vitro, pmid 32400338¿Sirve Lampaya para actividad antirreumática?
La investigación científica ha explorado el potencial de Lampaya (Lampaya medicinalis) en relación con actividad antirreumática. Se han identificado 7 estudios relevantes que examinan esta relación.
Compuestos activos involucrados: {'name': 'Ácido rosmarínico', 'class': 'Ácido fenólico'}, {'name': 'Luteolina', 'class': 'Flavona'}, {'name': 'Verbascósido', 'class': 'Feniletanoide'}, {'name': 'Ácido ursólico', 'class': 'Triterpeno'}, {'name': 'Hispidulina', 'class': 'Flavona'}, Aceite esencial, Apigenina, Carvacrol, Fenoles, Flavonoides, Glucósidos, Irido, Luteolina, Mucílagos, Terpenoides, Terpenos, Timol, ácido cafeico, ácido clorogénico, ácido oleanólico, ácido rosmarínico, ácido ursólico, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Lampaya y actividad antirreumática:
Acute oral toxicity and anti-inflammatory activity of hydroalcoholic extract from Lampaya medicinalis Phil in rats.
BACKGROUND: Algesia and inflammation are related with several pathological conditions. It is known that many drugs available for the treatment of these problems cause unwanted side effects. This study was aimed at evaluating acute toxicity and anti-inflammatory activity of Lampaya medicinalis Phil. (Verbenaceae) widely used in the folk medicine of Northern Chile against rheumatism, arthritis and body joints pain. RESULTS: Oral administration of hydroalcoholic extract (HAE) at the highest dose of 3000 mg/ Kg body weight resulted in no mortalities or evidence of significant behavioral changes.
PubMed: 25027298Hydroethanolic Extract of Lampaya Medicinalis Phil. (Verbenaceae) Decreases Proinflammatory Marker Expression in Palmitic Acid-exposed Macrophages.
BACKGROUND: Obesity is a major health problem associated with increased comorbidities, which are partially triggered by inflammation. Proinflammatory macrophage infiltration in adipose tissue of individuals with obesity increases chronic inflammation. Obesity is associated with elevated plasma levels of saturated fatty acids, such as palmitic acid (PA), which promotes inflammation in vivo and in vitro. Infusions of Lampaya medicinalis Phil. (Verbenaceae) are used in the folk medicine of Northern Chile to counteract inflammation of rheumatic diseases.
PubMed: 32400338Protective effect of the hydroalcoholic extract from Lampaya medicinalis Phil. (Verbenaceae) on palmitic acid- impaired insulin signaling in 3T3-L1 adipocytes.
BACKGROUND: Obesity is strongly associated with insulin resistance (IR). IR at the molecular level may be defined as a diminished activation of insulin signaling-related molecules (IRS-1/Akt/AS160) as well as reduced glucose uptake. Subject with obesity have elevated plasma levels of saturated fatty acids, such as palmitic acid (PA), which triggers insulin signaling disruption in vivo and in vitro. Infusions of Lampaya medicinalis Phil. (Verbenaceae) are used in folk medicine of Northern Chile to counteract inflammatory diseases.
PubMed: 33208251Lampaya Medicinalis Phil. decreases lipid-induced triglyceride accumulation and proinflammatory markers in human hepatocytes and fat body of Drosophila melanogaster.
BACKGROUND: Excess hepatic triglyceride (TG) accumulation (steatosis) commonly observed in obesity, may lead to non-alcoholic fatty liver disease (NAFLD). Altered regulation of intracellular lipid droplets (LD) and TG metabolism, as well as activation of JNK-mediated proinflammatory pathways may trigger liver steatosis-related disorders. Drosophila melanogaster is an animal model used for studying obesity and its associated disorders. In Drosophila, lipids and glycogen are stored in the fat body (FB), which resembles mammalian adipose tissue and liver. Dietary oversupply leads to obesity-relat
PubMed: 33895783Effect of
BACKGROUND: Aging and obesity are associated with insulin resistance (IR) and low-grade inflammation. Molecularly, IR is characterized by a reduction in glucose uptake and insulin signaling (IRS-1/Akt/AS160 pathway), while inflammation may result from upregulated NF-κB pathway after low Tyr-IκBα phosphorylation. Upregulated phosphatase activity of PTP1B is associated with impaired insulin signaling and increased inflammation. Plasma levels of palmitic acid (PA) are elevated in obesity, triggering inflammation and disruption of insulin signaling. Traditional medicine in Northern Chile uses oral
PubMed: 38794136Seguridad y Precauciones
Lampaya medicinalis tiene un perfil de seguridad favorable basado en el uso tradicional extenso por comunidades del altiplano andino durante siglos, aunque los estudios toxicológicos formales son limitados. El uso como infusión en las dosis tradicionales (2-3 tazas diarias de infusión preparada con 10-15 gramos de planta seca por litro) se considera seguro para adultos sanos, sustentado por la ausencia de reportes de toxicidad en la literatura etnobotánica y en las comunidades que la consumen regularmente. Los compuestos fenólicos y flavonoides presentes son generalmente bien tolerados. El verbascósido tiene un perfil de seguridad documentado en otras plantas que lo contienen. El ácido ursólico, presente en los extractos, tiene conocida actividad hepatoprotectora a dosis moderadas. No existen datos de seguridad específicos para embarazadas ni mujeres en periodo de lactancia.
Otras plantas estudiadas para Actividad antirreumática
Perfil completo: Ver todos los usos y evidencia de Lampaya →