Chuchuhuasi para Actividad antirreumática
Maytenus krukovii — 4 estudios científicos revisados
Preliminary¿Sirve Chuchuhuasi para actividad antirreumática?
La investigación científica ha explorado el potencial de Chuchuhuasi (Maytenus krukovii) en relación con actividad antirreumática. Se han identificado 4 estudios relevantes que examinan esta relación.
Compuestos activos involucrados: Alcaloides, Flavonoides, Terpenos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Chuchuhuasi y actividad antirreumática:
Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives.
This review article focuses on pre-clinical and clinical studies with some selected Brazilian medicinal plants in different areas of interest, conducted by research groups in Brazil and abroad. It also highlights the Brazilian market of herbal products and the efforts of Brazilian scientists to develop new phytomedicines. This review is divided into three sections. The section I describes the Brazilian large biodiversity and some attempts of Brazilian scientists to assess the pharmacological profile of most plant extracts or isolated active principles. Of note, Brazilian scientists have made a
PubMed: 26812486Maytenus heterophylla and Maytenus senegalensis, two traditional herbal medicines.
Maytenus heterophylla (Eckl. and Zeyh.) N.K.B. Robson and Maytenus senegalensis (Lam.) Exell are two African shrubs or trees that go under the common name of spike thorn, which belong to the Celastraceae family. Different plant parts of this species are largely used in traditional medicine for infectious and inflammatory diseases treatment. Several studies have been reported for both these species, but there are no recent review articles focusing microscopic, phytochemistry and pharmacological studies.
PubMed: 22470236Phenolic and quinone methide nor-triterpenes as selective NLRP3 inflammasome inhibitors.
Dysregulated inflammasome activity, particularly of the NLRP3 inflammasome, is associated with the development of several inflammatory diseases. The study of molecules directly targeting NLRP3 is an emerging field in the discovery of new therapeutic compounds for the treatment of inflammatory disorders. Friedelane triterpenes are biologically active phytochemicals having a wide range of activities including anti-inflammatory effects. In this work, we evaluated the potential anti-inflammatory activity of phenolic and quinonemethide nor-triterpenes (1-11) isolated from Maytenus retusa and some s
PubMed: 36657273Maytenus robusta Reissek, a medicinal plant popularly used to treat digestive diseases, promotes ameliorative effects in colon and liver of mice exposed to dextran sulfate sodium.
ETHNOPHARMACOLOGICAL RELEVANCE: Maytenus robusta Reissek (Celesteraceae), popularly named as cafezinho do mato or coração de bugre, is employed to treat inflammatory digestive diseases in the south of Brazil. However, despite popular usage, the effects of this species on an experimental model of ulcerative colitis are unknown. AIM OF THE STUDY: To evaluate the effects of M. robusta extract (HEMR) on colon and liver from mice with colitis induced by dextran sulfate sodium (DSS). MATERIALS AND METHODS: Firstly, the cytotoxicity of HEMR and its effects on ROS and nitrite production in IEC-6 cells
PubMed: 32730884Seguridad y Precauciones
El uso de la corteza de Chuchuhuasi (Maytenus krukovii) conlleva riesgos significativos que deben ser evaluados con extrema precaución debido a la carencia de estudios clínicos robustos en humanos que garanticen su inocuidad absoluta. En relación con el embarazo y la lactancia, la evidencia científica es alarmante respecto al consumo de plantas medicinales en estas etapas. Según el estudio de revisión [PMID 33164294], el uso de fitoquímicos durante la gestación puede provocar efectos embriotóxicos, teratogénicos (malformaciones congénitas) y abortivos. Aunque no se han detallado estudios específicos de toxicidad reproductiva para la especie Maytenus krukovii, se advierte que muchos componentes vegetales pueden atravesar la barrera placentaria, alterando el perfil hormonal o estimulando contracciones uterinas que podrían interrumpir el embarazo. Por lo tanto, su uso en mujeres embarazadas está contraindicado por precaución extrema. En cuanto a la población infantil, no se ha establecido una dosis segura para niños menores de 12 años; la falta de datos farmacocinéticos en pediatría hace que su administración sea altamente riesgosa debido al potencial de toxicidad sistémica en organismos en desarrollo.
Otras plantas estudiadas para Actividad antirreumática
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