Chuchuhuasi para Actividad antirreumática
Maytenus laevis — 5 estudios científicos revisados
Preliminary¿Sirve Chuchuhuasi para actividad antirreumática?
La investigación científica ha explorado el potencial de Chuchuhuasi (Maytenus laevis) en relación con actividad antirreumática. Se han identificado 5 estudios relevantes que examinan esta relación.
Compuestos activos involucrados: Alcaloides, Canophyllol, Catequina, Fenol, Flavonoides, Terpenos, Compuestos fenólicos, Isopreno
Evidencia Científica
Los siguientes estudios han investigado la relación entre Chuchuhuasi y actividad antirreumática:
Chuchuhuasha - a drug used in folk medicine in the Amazonian and Andean areas. A chemical study of Maytenus laevis.
In the high Amazonian basin a plant named chuchuasha, (or chuchuaso) is used in traditional medicine for several purposes in the form of an alcoholic extract. This plant, a Maytenus species, most probably Maytenus laevis, grows in the subandean region of the Amazonian basin (Peru, Ecuador, Colombia). Antitumor and anti-inflammatory properties were recently attributed to the extracts of the root bark of the plant. The composition of the extract of M. laevis from the Putumayo area of Colombia was studied in order to establish the active principle responsible for these activities.
PubMed: 7033668Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives.
This review article focuses on pre-clinical and clinical studies with some selected Brazilian medicinal plants in different areas of interest, conducted by research groups in Brazil and abroad. It also highlights the Brazilian market of herbal products and the efforts of Brazilian scientists to develop new phytomedicines. This review is divided into three sections. The section I describes the Brazilian large biodiversity and some attempts of Brazilian scientists to assess the pharmacological profile of most plant extracts or isolated active principles. Of note, Brazilian scientists have made a
PubMed: 26812486Maytenus heterophylla and Maytenus senegalensis, two traditional herbal medicines.
Maytenus heterophylla (Eckl. and Zeyh.) N.K.B. Robson and Maytenus senegalensis (Lam.) Exell are two African shrubs or trees that go under the common name of spike thorn, which belong to the Celastraceae family. Different plant parts of this species are largely used in traditional medicine for infectious and inflammatory diseases treatment. Several studies have been reported for both these species, but there are no recent review articles focusing microscopic, phytochemistry and pharmacological studies.
PubMed: 22470236Phenolic and quinone methide nor-triterpenes as selective NLRP3 inflammasome inhibitors.
Dysregulated inflammasome activity, particularly of the NLRP3 inflammasome, is associated with the development of several inflammatory diseases. The study of molecules directly targeting NLRP3 is an emerging field in the discovery of new therapeutic compounds for the treatment of inflammatory disorders. Friedelane triterpenes are biologically active phytochemicals having a wide range of activities including anti-inflammatory effects. In this work, we evaluated the potential anti-inflammatory activity of phenolic and quinonemethide nor-triterpenes (1-11) isolated from Maytenus retusa and some s
PubMed: 36657273Maytenus robusta Reissek, a medicinal plant popularly used to treat digestive diseases, promotes ameliorative effects in colon and liver of mice exposed to dextran sulfate sodium.
ETHNOPHARMACOLOGICAL RELEVANCE: Maytenus robusta Reissek (Celesteraceae), popularly named as cafezinho do mato or coração de bugre, is employed to treat inflammatory digestive diseases in the south of Brazil. However, despite popular usage, the effects of this species on an experimental model of ulcerative colitis are unknown. AIM OF THE STUDY: To evaluate the effects of M. robusta extract (HEMR) on colon and liver from mice with colitis induced by dextran sulfate sodium (DSS). MATERIALS AND METHODS: Firstly, the cytotoxicity of HEMR and its effects on ROS and nitrite production in IEC-6 cells
PubMed: 32730884Seguridad y Precauciones
La seguridad del uso de Chuchuhuasi (Maytenus laevis) es un área con una brecha significativa entre el conocimiento tradicional de los pueblos amazónicos y la evidencia científica rigurosa. En cuanto al embarazo y la lactancia, existe una precaución extrema que debe observarse. Aunque la literatura científica señala que muchos productos herbales carecen de estudios de seguridad específicos, se advierte que los fitoquímicos pueden cruzar la placenta, lo que conlleva riesgos de efectos teratogénicos (malformaciones congénitas), embriotoxicidad o incluso efectos abortivos debido a la posible estimulación de contracciones uterinas o alteraciones en el perfil hormonal del organismo materno (PMID 33164294). No existe evidencia que garantice la seguridad para el lactante, por lo que se recomienda evitar su consumo durante este periodo. Para niños menores de 12 años, el uso de extractos de Chuchuhuasi no está recomendado debido a la ausencia de estudios de toxicidad pediátrica y la falta de datos sobre el impacto de sus alcaloides y compuestos fenólicos en sistemas en desarrollo. Respecto a las interacciones farmacológicas, el consumo de Chuchuhuasi requiere vigilancia si el paciente utiliza fármacos que afecten la coagulación, como la warfarina, dado que la planta contiene una compleja mezcla de compuestos como fenoldienonas y proantocianidinas que podrían alterar la respuesta hemática.
Otras plantas estudiadas para Actividad antirreumática
Perfil completo: Ver todos los usos y evidencia de Chuchuhuasi →