Chuchuhuasi para Actividad antirreumática
Maytenus macrocarpa — 5 estudios científicos revisados
Preliminary¿Sirve Chuchuhuasi para actividad antirreumática?
La investigación científica ha explorado el potencial de Chuchuhuasi (Maytenus macrocarpa) en relación con actividad antirreumática. Se han identificado 5 estudios relevantes que examinan esta relación.
Compuestos activos involucrados: Alcaloides, Flavonoides, Friedelina, Saponinas, Terpenos, Triterpeno
Evidencia Científica
Los siguientes estudios han investigado la relación entre Chuchuhuasi y actividad antirreumática:
Maytenus macrocarpa (Ruiz & Pav.) Briq.: Phytochemistry and Pharmacological Activity.
Maytenus macrocarpa (Celastraceae) is a tree native to Amazonia. Its roots, leaves, bark, and combinations of these are used in traditional medicine mainly to treat rheumatism and, to a lesser extent, to heal wounds and to combat bronchitis and diarrhea. To date, mainly triterpenes and dihydro-β-agarofuran sesquiterpenes were isolated from M. macrocarpa. Extracts and selected pure compounds isolated from the leaves, roots, and stem bark showed antibacterial, antiviral, antiparasitic, anti-inflammatory, and cytotoxic activities in vitro.
PubMed: 31226757Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives.
This review article focuses on pre-clinical and clinical studies with some selected Brazilian medicinal plants in different areas of interest, conducted by research groups in Brazil and abroad. It also highlights the Brazilian market of herbal products and the efforts of Brazilian scientists to develop new phytomedicines. This review is divided into three sections. The section I describes the Brazilian large biodiversity and some attempts of Brazilian scientists to assess the pharmacological profile of most plant extracts or isolated active principles. Of note, Brazilian scientists have made a
PubMed: 26812486Maytenus heterophylla and Maytenus senegalensis, two traditional herbal medicines.
Maytenus heterophylla (Eckl. and Zeyh.) N.K.B. Robson and Maytenus senegalensis (Lam.) Exell are two African shrubs or trees that go under the common name of spike thorn, which belong to the Celastraceae family. Different plant parts of this species are largely used in traditional medicine for infectious and inflammatory diseases treatment. Several studies have been reported for both these species, but there are no recent review articles focusing microscopic, phytochemistry and pharmacological studies.
PubMed: 22470236Phenolic and quinone methide nor-triterpenes as selective NLRP3 inflammasome inhibitors.
Dysregulated inflammasome activity, particularly of the NLRP3 inflammasome, is associated with the development of several inflammatory diseases. The study of molecules directly targeting NLRP3 is an emerging field in the discovery of new therapeutic compounds for the treatment of inflammatory disorders. Friedelane triterpenes are biologically active phytochemicals having a wide range of activities including anti-inflammatory effects. In this work, we evaluated the potential anti-inflammatory activity of phenolic and quinonemethide nor-triterpenes (1-11) isolated from Maytenus retusa and some s
PubMed: 36657273Maytenus robusta Reissek, a medicinal plant popularly used to treat digestive diseases, promotes ameliorative effects in colon and liver of mice exposed to dextran sulfate sodium.
ETHNOPHARMACOLOGICAL RELEVANCE: Maytenus robusta Reissek (Celesteraceae), popularly named as cafezinho do mato or coração de bugre, is employed to treat inflammatory digestive diseases in the south of Brazil. However, despite popular usage, the effects of this species on an experimental model of ulcerative colitis are unknown. AIM OF THE STUDY: To evaluate the effects of M. robusta extract (HEMR) on colon and liver from mice with colitis induced by dextran sulfate sodium (DSS). MATERIALS AND METHODS: Firstly, the cytotoxicity of HEMR and its effects on ROS and nitrite production in IEC-6 cells
PubMed: 32730884Seguridad y Precauciones
La seguridad del uso de Chuchuhuasi (Maytenus macrocarpa) es un área que requiere extrema precaución debido a la falta de estudios clínicos extensos en humanos que establezcan parámetros de toxicidad aguda o crónica. En cuanto al embarazo y la lactancia, no existen estudios científicos que garanticen la inocuidad de sus compuestos, como los triterpenos y sesquiterpenos, en mujeres gestantes o lactantes; por lo tanto, su uso está estrictamente contraindicado en estos periodos para evitar riesgos potenciales de teratogenicidad o transferencia de metabolitos a través de la leche materna, dado que la seguridad fetal no ha sido establecida. En niños menores de 12 años, el uso debe evitarse por completo, ya que los sistemas metabólicos en desarrollo podrían verse afectados por la complejidad química de la corteza y las raíces. Respecto a las interacciones farmacológicas, existe un riesgo teórico significativo con fármacos que afectan la coagulación, como la warfarina, debido a la presencia de múltiples triterpenos que podrían alterar la homeostasis sanguínea. Asimismo, se debe tener precaución con la metformina y otros agentes hipoglucemiantes, ya que la actividad biológica de la planta podría interferir con el metabolismo de la glucosa. En pacientes que utilizan antihipertensivos, el uso de Chuchuhuasi podría potenciar o antagonizar los efectos sobre la presión arterial de manera impredecible.
Otras plantas estudiadas para Actividad antirreumática
Perfil completo: Ver todos los usos y evidencia de Chuchuhuasi →